[(3R,5S)-7-Chloro-5-(2,3-dimethoxy-phenyl)-1-(2,2-dimethyl-propyl)-2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]oxazepin-3-yl]-acetic acid ethyl ester

Base Information

Chemical Name:[(3R,5S)-7-Chloro-5-(2,3-dimethoxy-phenyl)-1-(2,2-dimethyl-propyl)-2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]oxazepin-3-yl]-acetic acid ethyl ester
CAS No.:177567-40-7
Molecular Formula:C₂₆H₃₂ClNO₆
Molecular Weight:489.996
Hs Code.:

Synonyms:[(3R,5S)-7-Chloro-5-(2,3-dimethoxy-phenyl)-1-(2,2-dimethyl-propyl)-2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]oxazepin-3-yl]-acetic acid ethyl ester

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Chemical Property of [(3R,5S)-7-Chloro-5-(2,3-dimethoxy-phenyl)-1-(2,2-dimethyl-propyl)-2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]oxazepin-3-yl]-acetic acid ethyl ester

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Technology Process of [(3R,5S)-7-Chloro-5-(2,3-dimethoxy-phenyl)-1-(2,2-dimethyl-propyl)-2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]oxazepin-3-yl]-acetic acid ethyl ester

There total 8 articles about [(3R,5S)-7-Chloro-5-(2,3-dimethoxy-phenyl)-1-(2,2-dimethyl-propyl)-2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]oxazepin-3-yl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 177567-44-1
(E)-3-[{4-Chloro-2-[(S)-(2,3-dimethoxy-phenyl)-hydroxy-methyl]-phenyl}-(2,2-dimethyl-propyl)-carbamoyl]-acrylic acid ethyl ester

: 177567-40-7
[(3R,5S)-7-Chloro-5-(2,3-dimethoxy-phenyl)-1-(2,2-dimethyl-propyl)-2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]oxazepin-3-yl]-acetic acid ethyl ester

Guidance literature:: With potassium carbonate; In ethanol; at 20 ℃; for 3h;
DOI:10.1248/cpb.50.59

Reference yield:

: 152911-54-1
(+/-)-2-amino-5-chloro-α-(2,3-dimethoxyphenyl)benzyl alcohol

: 177567-40-7
[(3R,5S)-7-Chloro-5-(2,3-dimethoxy-phenyl)-1-(2,2-dimethyl-propyl)-2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]oxazepin-3-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / NaHCO₃; DMAP / ethyl acetate / 1 h / 20 °C

2: 86 percent / pyridine; DMAP / 1 h / 20 °C

3: 25 percent / Pseudomonas sp. S-13; H₂O / methanol; various solvent(s) / 24 h / 28 °C

4: 86 percent / NaOH / ethanol / 3 h / Heating

5: 73 percent / NaBH₄; AcOH / 0.33 h / 20 °C

6: 99 percent / NaHCO₃ / ethyl acetate / 0.67 h / 20 °C

7: 75 percent / K₂CO₃ / ethanol / 3 h / 20 °C

With pyridine; dmap; sodium hydroxide; sodium tetrahydroborate; Pseudomonas sp. S-13; water; sodium hydrogencarbonate; potassium carbonate; acetic acid; In methanol; ethanol; ethyl acetate;
DOI:10.1248/cpb.50.59

Reference yield:

: 177410-73-0
(+/-)-5-chloro-α-(2,3-dimethoxyphenyl)-2-pivaloylaminobenzyl alcohol

: 177567-40-7
[(3R,5S)-7-Chloro-5-(2,3-dimethoxy-phenyl)-1-(2,2-dimethyl-propyl)-2-oxo-1,2,3,5-tetrahydro-benzo[e][1,4]oxazepin-3-yl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 86 percent / pyridine; DMAP / 1 h / 20 °C

2: 25 percent / Pseudomonas sp. S-13; H₂O / methanol; various solvent(s) / 24 h / 28 °C

3: 86 percent / NaOH / ethanol / 3 h / Heating

4: 73 percent / NaBH₄; AcOH / 0.33 h / 20 °C

5: 99 percent / NaHCO₃ / ethyl acetate / 0.67 h / 20 °C

6: 75 percent / K₂CO₃ / ethanol / 3 h / 20 °C

With pyridine; dmap; sodium hydroxide; sodium tetrahydroborate; Pseudomonas sp. S-13; water; sodium hydrogencarbonate; potassium carbonate; acetic acid; In methanol; ethanol; ethyl acetate;
DOI:10.1248/cpb.50.59