2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxylic acid

Base Information

Chemical Name:2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxylic acid
CAS No.:1450658-95-3
Molecular Formula:C₁₇H₂₁NO₃
Molecular Weight:287.359
Hs Code.:

Synonyms:2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxylic acid

Suppliers and Price of 2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxylic acid

There total 1 articles about 2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50675-18-8
3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

: 1450658-95-3
2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.25 h / 0 °C

2.2: 4 h / 0 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 12 h / 70 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

5.1: acetic acid / ethanol / 12 h / 85 °C

6.1: sodium methylate / 1,4-dioxane / 0.25 h / Inert atmosphere

6.2: 12.25 h / 100 °C / Inert atmosphere

7.1: sodium hydroxide / ethanol / 4 h / Reflux

With sodium azide; palladium 10% on activated carbon; hydrogen; sodium methylate; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1438382-15-0
3-(aminomethyl)-4-methoxy-6-methylpyridin-2(1H)-one

: 1450658-95-3
2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxylic acid

: 1450654-49-5,1802175-06-9
N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dimethyl sulfoxide; at 0 - 20 ℃; for 16.25h;

Reference yield:

: 1438382-15-0
3-(aminomethyl)-4-methoxy-6-methylpyridin-2(1H)-one

: 1450658-95-3
2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxylic acid

: 1802175-06-9
(R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide

: 1802175-06-9
(S)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dimethyl sulfoxide / 16.25 h / 0 - 20 °C

2: Chiralpak IA column / methanol; dichloromethane; hexane; diethylamine / Resolution of racemate

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In methanol; hexane; dichloromethane; dimethyl sulfoxide; diethylamine;