4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1-[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide

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Chemical Name:4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1-[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide
CAS No.:1610853-10-5
Molecular Formula:C₂₂H₂₈F₃N₃O₃S
Molecular Weight:471.544
Hs Code.:

Synonyms:4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1-[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide

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Chemical Property of 4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1-[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide

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Technology Process of 4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1-[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide

There total 6 articles about 4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1-[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 477312-25-7,1228542-85-5,1228559-55-4
1-[3-(trifluoromethyloxy)-phenyl]-ethyl-amine

: 1514568-53-6
4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-thiazole-5-carboxylic acid

: 1610853-10-5
4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1-[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide

Guidance literature:: 4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-thiazole-5-carboxylic acid; With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

1-[3-(trifluoromethyloxy)-phenyl]-ethyl-amine; In N,N-dimethyl-formamide; at 23 ℃; for 16h;

Reference yield:

: 7152-15-0
ethyl 4-methyl-3-oxo-pentanoate

: 1610853-10-5
4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1-[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / water; tetrachloromethane / 2 h / 0 °C

2.1: ethanol / 1 h / 23 - 100 °C

3.1: sodium bromide; copper(ll) sulfate pentahydrate; sulfuric acid; sodium nitrite / water / 1.5 h / -10 - 10 °C

4.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 16 h / 23 - 150 °C

5.1: potassium hydroxide / water; ethanol / 16 h / 23 - 120 °C

6.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h / 0 °C

6.2: 16 h / 23 °C

With 4-methyl-morpholine; copper(ll) sulfate pentahydrate; sulfuric acid; bromine; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium bromide; potassium hydroxide; sodium nitrite; In 1-methyl-pyrrolidin-2-one; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 81569-67-7
2-bromo-4-methyl-3-oxo-pentanoic acid ethyl ester

: 1610853-10-5
4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1-[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 1 h / 23 - 100 °C

2.1: sodium bromide; copper(ll) sulfate pentahydrate; sulfuric acid; sodium nitrite / water / 1.5 h / -10 - 10 °C

3.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 16 h / 23 - 150 °C

4.1: potassium hydroxide / water; ethanol / 16 h / 23 - 120 °C

5.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h / 0 °C

5.2: 16 h / 23 °C

With 4-methyl-morpholine; copper(ll) sulfate pentahydrate; sulfuric acid; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; sodium bromide; potassium hydroxide; sodium nitrite; In 1-methyl-pyrrolidin-2-one; ethanol; water; N,N-dimethyl-formamide;