5-Thiazolecarboxylicacid,2-bromo-4-(1-methylethyl)-,ethylester(9CI)

Base Information

• Chemical Name: 5-Thiazolecarboxylicacid,2-bromo-4-(1-methylethyl)-,ethylester(9CI)
• CAS No.: 81569-58-6
• Molecular Formula: C9H12 Br N O2 S
• Molecular Weight: 278.17
• Hs Code.: 2934100090
• Mol file: 81569-58-6.mol

Synonyms:Ethyl2-bromo-4-isopropyl-1,3-thiazole-5-carboxylate; Ethyl2-bromo-4-isopropylthiazole-5-carboxylate

Chemical Property of 5-Thiazolecarboxylicacid,2-bromo-4-(1-methylethyl)-,ethylester(9CI)

Chemical Property:

• PSA: 67.43000
• LogP: 3.20570
• Storage Temp.: 2-8°C

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Ethyl2-bromo-4-isopropylthiazole-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Thiazolecarboxylicacid,2-bromo-4-(1-methylethyl)-,ethylester(9CI)

There total 4 articles about 5-Thiazolecarboxylicacid,2-bromo-4-(1-methylethyl)-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

→ 2-bromo-4-isopropyl-thiazole-5-carboxylic acid ethyl ester (81569-58-6)

Guidance literature:

Reference yield: 90.0%

ethyl 2-amino-4-isopropyl-1,3-thiazole-5-carboxylate (72850-76-1) → 2-bromo-4-isopropyl-thiazole-5-carboxylic acid ethyl ester (81569-58-6)

Guidance literature:

With copper(I) bromide; isopentyl nitrite; In acetonitrile; at 80 ℃; for 3h;

Reference yield:

2-bromo-4-methyl-3-oxo-pentanoic acid ethyl ester (81569-67-7) → 2-bromo-4-isopropyl-thiazole-5-carboxylic acid ethyl ester (81569-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: NaBr, CuSO₄, H₂SO₄, NaNO₂ / H₂O

With sulfuric acid; copper(II) sulfate; sodium bromide; sodium nitrite; In ethanol; water;

upstream raw materials:

ethyl 2-amino-4-isopropyl-1,3-thiazole-5-carboxylate

2-bromo-4-methyl-3-oxo-pentanoic acid ethyl ester

ethyl 4-methyl-3-oxo-pentanoate

Downstream raw materials:

4-isopropyl-2-(methyl-tetrahydro-pyran-4-yl-amino)-N-[1-[3-(trifluoromethyloxy)-phenyl]-ethyl]-thiazole-5-carboxylic acid amide