3',3'-dimethyl-1-phenyl-3,3-bis(trifluoromethyl)spiro[3H-2,1-benzoxaphosphole-1,2'λ⁵-[1,2]selenaphosphirane]

Base Information

• Chemical Name: 3',3'-dimethyl-1-phenyl-3,3-bis(trifluoromethyl)spiro[3H-2,1-benzoxaphosphole-1,2'λ⁵-[1,2]selenaphosphirane]
• CAS No.: 461679-38-9
• Molecular Formula: C₁₈H₁₅F₆OPSe
• Molecular Weight: 471.241

Synonyms:3',3'-dimethyl-1-phenyl-3,3-bis(trifluoromethyl)spiro[3H-2,1-benzoxaphosphole-1,2'λ⁵-[1,2]selenaphosphirane]

Chemical Property of 3',3'-dimethyl-1-phenyl-3,3-bis(trifluoromethyl)spiro[3H-2,1-benzoxaphosphole-1,2'λ⁵-[1,2]selenaphosphirane]

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Technology Process of 3',3'-dimethyl-1-phenyl-3,3-bis(trifluoromethyl)spiro[3H-2,1-benzoxaphosphole-1,2'λ⁵-[1,2]selenaphosphirane]

There total 2 articles about 3',3'-dimethyl-1-phenyl-3,3-bis(trifluoromethyl)spiro[3H-2,1-benzoxaphosphole-1,2'λ⁵-[1,2]selenaphosphirane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1,1,1,3-tetrahydro-1-isopropylidene-1-phenyl-3,3-bis(trifluoromethyl)-2,1-benzoxaphosphole (461679-37-8) → 3',3'-dimethyl-1-phenyl-3,3-bis(trifluoromethyl)spiro[3H-2,1-benzoxaphosphole-1,2'λ5-[1,2]selenaphosphirane] (461679-38-9)

Guidance literature:

With selenium; In tetrahydrofuran; at 20 ℃; for 0.166667h;

DOI:10.1021/ja026107z

Reference yield:

1-fluoro-1-isopropyl-1-phenyl-3,3-bis-trifluoromethyl-2-oxa-1λ5-phospha-indan (434321-76-3) → 3',3'-dimethyl-1-phenyl-3,3-bis(trifluoromethyl)spiro[3H-2,1-benzoxaphosphole-1,2'λ5-[1,2]selenaphosphirane] (461679-38-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: TMSOSO₂CF₃ / diethyl ether / 20 °C

1.2: 2,4,6-trimethylphenyllithium / tetrahydrofuran / -72 °C

2.1: 85 percent / Cp₂TiSe₅ / tetrahydrofuran / 20 °C

With trimethylsilyl trifluoromethanesulfonate; Cp₂TiSe₅; In tetrahydrofuran; diethyl ether;

DOI:10.1080/10426500213458

Reference yield:

methyl trifluoromethanesulfonate (333-27-7) + 3',3'-dimethyl-1-phenyl-3,3-bis(trifluoromethyl)spiro[3H-2,1-benzoxaphosphole-1,2'λ5-[1,2]selenaphosphirane] (461679-38-9) → 1,3-dihydro-1-[1-methyl-1-(methylseleno)ethyl]-1-phenyl-3,3-bis(trifluoromethyl)-2,1-benzoxaphospholium trifluoromethanesulfonate

Guidance literature:

In chloroform-d1;

DOI:10.1021/ja026107z

upstream raw materials:

1,1,1,3-tetrahydro-1-isopropylidene-1-phenyl-3,3-bis(trifluoromethyl)-2,1-benzoxaphosphole

1-fluoro-1-isopropyl-1-phenyl-3,3-bis-trifluoromethyl-2-oxa-1λ⁵-phospha-indan

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