Technology Process of 6-(4-{1-[(2-chloro-4-fluorophenyl)methyl]piperidin-4-yl}-5,5-dideutero-1,4-diazepan-1-yl)-N-(pyridin-4-yl)pyridine-2-carboxamide
There total 6 articles about 6-(4-{1-[(2-chloro-4-fluorophenyl)methyl]piperidin-4-yl}-5,5-dideutero-1,4-diazepan-1-yl)-N-(pyridin-4-yl)pyridine-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-[5,5-dideutero-4-(piperidin-4-yl)-1,4-diazepan-1-yl]-N-(pyridin-4-yl)pyridine-2-carboxamide; 2-chloro-4-fluorobenzaldehyde;
With
sodium tris(acetoxy)borohydride;
In
dichloromethane;
at 20 ℃;
for 18h;
With
water; sodium carbonate;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
3: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 18 h / 95 °C
4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
5: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C
With
oxalyl dichloride; palladium diacetate; sodium tris(acetoxy)borohydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid;
In
1,4-dioxane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
2: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 18 h / 95 °C
3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
4: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C
With
palladium diacetate; sodium tris(acetoxy)borohydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
1,4-dioxane; dichloromethane;