(S)-2-methyl-2-methyl⁽¹³⁾-3-phenyl-propionic acid methyl ester

Base Information

• Chemical Name: (S)-2-methyl-2-methyl⁽¹³⁾-3-phenyl-propionic acid methyl ester
• CAS No.: 457064-00-5
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 193.247
• Mol file: 457064-00-5.mol

Synonyms:(S)-2-methyl-2-methyl⁽¹³⁾-3-phenyl-propionic acid methyl ester

Chemical Property of (S)-2-methyl-2-methyl⁽¹³⁾-3-phenyl-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (S)-2-methyl-2-methyl⁽¹³⁾-3-phenyl-propionic acid methyl ester

There total 1 articles about (S)-2-methyl-2-methyl⁽¹³⁾-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-2-methyl-2-methyl(13)-3-phenyl-propionic acid methyl ester → C11(13)CH16O2 + (S)-2-methyl-2-methyl(13)-3-phenyl-propionic acid methyl ester (457064-00-5)

Guidance literature:

With tetrafluoroboric acid; dimethylethylsilane; In dichloromethane; at 40 ℃; for 30h; Title compound not separated from byproducts.;

DOI:10.1021/ja026703t

Reference yield: 59.0%

trimethylsilylmethyllithium (1822-00-0) + (S)-2-methyl-2-methyl(13)-3-phenyl-propionic acid methyl ester (457064-00-5) → (S)-3-methyl-3-methyl(13)-4-phenyl-butan-2-one (457064-01-6)

Guidance literature:

With triethylsilyl methyllithium; In pentane; at 0 ℃; for 0.1h;

DOI:10.1021/ja026703t

Reference yield:

(S)-2-methyl-2-methyl(13)-3-phenyl-propionic acid methyl ester (457064-00-5) → C10(13)CH14O

Guidance literature:

(S)-2-methyl-2-methyl⁽¹³⁾-3-phenyl-propionic acid methyl ester; With diisobutylaluminium hydride;

Further stages.;

DOI:10.1021/ja026703t

Downstream raw materials:

(S)-3-methyl-3-methyl⁽¹³⁾-4-phenyl-butan-2-one