methyl 5E-6-(3-(2,3-dioxo-4-ethoxy-cyclobut-4-enyl)aminophenyl)-6-(3-pyridyl)hex-5-enoate

Base Information

• Chemical Name: methyl 5E-6-(3-(2,3-dioxo-4-ethoxy-cyclobut-4-enyl)aminophenyl)-6-(3-pyridyl)hex-5-enoate
• CAS No.: 223754-21-0
• Molecular Formula: C₂₄H₂₄N₂O₅
• Molecular Weight: 420.465
• Mol file: 223754-21-0.mol

Synonyms:methyl 5E-6-(3-(2,3-dioxo-4-ethoxy-cyclobut-4-enyl)aminophenyl)-6-(3-pyridyl)hex-5-enoate

Chemical Property of methyl 5E-6-(3-(2,3-dioxo-4-ethoxy-cyclobut-4-enyl)aminophenyl)-6-(3-pyridyl)hex-5-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5E-6-(3-(2,3-dioxo-4-ethoxy-cyclobut-4-enyl)aminophenyl)-6-(3-pyridyl)hex-5-enoate

There total 1 articles about methyl 5E-6-(3-(2,3-dioxo-4-ethoxy-cyclobut-4-enyl)aminophenyl)-6-(3-pyridyl)hex-5-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3,4-diethoxy-3-cyclobuten-1,2-dione (5231-87-8) + (E)-methyl 6-(3-aminophenyl)-6-(3-pyridyl)hex-5-enoate (149980-31-4) → methyl 5E-6-(3-(2,3-dioxo-4-ethoxy-cyclobut-4-enyl)aminophenyl)-6-(3-pyridyl)hex-5-enoate (223754-21-0)

Guidance literature:

In isopropyl alcohol; at 25 ℃; for 20h;

DOI:10.1021/jm9707941

Reference yield:

methyl 5E-6-(3-(2,3-dioxo-4-ethoxy-cyclobut-4-enyl)aminophenyl)-6-(3-pyridyl)hex-5-enoate (223754-21-0) → 6-[3-(2-tert-butylamino-3,4-dioxo-cyclobut-1-enylamino)-phenyl]-6-pyridin-3-yl-hex-5-enoic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 2.38 g / propan-2-ol / 48 h / 25 °C

2: 60 percent / 2 M aq. NaOH / propan-2-ol / 4 h / 25 °C

With sodium hydroxide; In isopropyl alcohol;

DOI:10.1021/jm9707941

Reference yield:

tert-butylamine (75-64-9) + methyl 5E-6-(3-(2,3-dioxo-4-ethoxy-cyclobut-4-enyl)aminophenyl)-6-(3-pyridyl)hex-5-enoate (223754-21-0) → 6-[3-(2-tert-butylamino-3,4-dioxo-cyclobut-1-enylamino)-phenyl]-6-pyridin-3-yl-hex-5-enoic acid methyl ester

Guidance literature:

In isopropyl alcohol; at 25 ℃; for 48h;

DOI:10.1021/jm9707941

upstream raw materials:

3,4-diethoxy-3-cyclobuten-1,2-dione

(E)-methyl 6-(3-aminophenyl)-6-(3-pyridyl)hex-5-enoate