N-[2-(3,4-dimethoxyphenyl)cyclohexen-1-yl]-N-methyl-α-(methylthio)acetamide

Base Information

• Chemical Name: N-[2-(3,4-dimethoxyphenyl)cyclohexen-1-yl]-N-methyl-α-(methylthio)acetamide
• CAS No.: 943229-15-0
• Molecular Formula: C₁₈H₂₅NO₃S
• Molecular Weight: 335.467

Synonyms:N-[2-(3,4-dimethoxyphenyl)cyclohexen-1-yl]-N-methyl-α-(methylthio)acetamide

Chemical Property of N-[2-(3,4-dimethoxyphenyl)cyclohexen-1-yl]-N-methyl-α-(methylthio)acetamide

Chemical Property:

Purity/Quality:

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Technology Process of N-[2-(3,4-dimethoxyphenyl)cyclohexen-1-yl]-N-methyl-α-(methylthio)acetamide

There total 2 articles about N-[2-(3,4-dimethoxyphenyl)cyclohexen-1-yl]-N-methyl-α-(methylthio)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H21NO2 + (methylthio)acetyl chloride (35928-65-5) → N-[2-(3,4-dimethoxyphenyl)cyclohexen-1-yl]-N-methyl-α-(methylthio)acetamide (943229-15-0)

Guidance literature:

With dmap; N,N-dimethyl-aniline; In toluene; at 20 ℃; for 0.166667h;

DOI:10.1016/j.tet.2007.03.153

Reference yield:

2-(3,4-dimethoxyphenyl)cyclohexanone (5227-11-2) → N-[2-(3,4-dimethoxyphenyl)cyclohexen-1-yl]-N-methyl-α-(methylthio)acetamide (943229-15-0)

Guidance literature:

Multi-step reaction with 2 steps

1: MS 4 Angstroem / toluene / 17 h / 110 °C

2: 371 mg / N,N-dimethylaniline; 4-dimethylaminopyridine / toluene / 0.17 h / 20 °C

With dmap; MS 4 Angstroem; N,N-dimethyl-aniline; In toluene;

DOI:10.1016/j.tet.2007.03.153

Reference yield: 48.0%

N-[2-(3,4-dimethoxyphenyl)cyclohexen-1-yl]-N-methyl-α-(methylthio)acetamide (943229-15-0) → (3R*,3aS*)-2,3,3a,4,5,6-hexahydro-3a-(3,4-dimethoxyphenyl)-1-methyl-3-(methylthio)indol-2-one

Guidance literature:

With N-chloro-succinimide; In tetrachloromethane; at 20 ℃; for 2.5h;

DOI:10.1016/j.tet.2007.03.153

upstream raw materials:

(methylthio)acetyl chloride

2-(3,4-dimethoxyphenyl)cyclohexanone

Downstream raw materials:

(3aS^*,7aS^*)-3a-(3,4-dimethoxyphenyl)-1-methyloctahydroindole

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