5227-11-2

Usage

Structure

Cyclohexanone derivative with a phenyl ring and two methoxy groups attached at the 3 and 4 positions

Usage

Organic synthesis, pharmaceutical research, development of new drugs, and medicinal compounds

Applications

Materials science and as a precursor for the synthesis of various organic compounds

Biological activity

Potential for biological activity

Building block

Can be used as a building block for more complex molecules

Upstream product

• 2859-78-1 4-Bromoveratrole 
• 108-94-1 cyclohexanone 
• 5227-09-8 (+/-)-cis-1,2-Dimethoxy-4-(2-nitrocyclohex-4-enyl)benzene 
• 4230-93-7 3,4-dimethoxynitrostyrene 
• 5227-10-1 6-<3,4-Dimethoxy-phenyl>-3-cyclohexen-1-on 

Downstream Products

• 5227-12-3 2-allyl-2-(3,4-dimethoxyphenyl)cyclohexan-1-one 
• 926013-34-5 N-[2-(3,4-dimethoxyphenyl)cyclohexen-1-yl]-α-(methylthio)-N-[(R)-1-(1-naphtyhl)ethyl]acetamide 
• 926013-38-9 2,3,3a,4,5,6-hexahydro-3a-(3,4-dimethoxyphenyl)-3-methylthio-1-[(R)-1-(1-naphthyl)ethyl]indol-2-one 
• 926013-40-3 2,3,3a,4,5,6-hexahydro-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1-naphthyl)ethyl]indol-2-one 
• 203245-01-6 N-methyl-2,2,2-trichloro-N-[2-(3,4-dimethoxyphenyl)-cyclohex-1-enyl]-acetamide 
• 203245-07-2 N-benzyl-2,2,2-trichloro-N-[2-(3,4-dimethoxyphenyl)-cyclohex-1-enyl]-acetamide 

Relevant academic research and scientific papers

Aromatic compound, preparation method and use of aromatic compound

The invention relates to an aromatic compound, a preparation method and use of the aromatic compound, andspecifically discloses a compound represented by the following formula (I), or a tautomer or anenantiomer or a diastereomer or a racemate of the compound or a mixture of the compound or a pharmaceutically acceptable salt of the compound. The invention further discloses a preparation method ofthe compound and application of the compound in treating nervous systemdiseases.

TETRAHYDRO-BENZOIMIDAZOLYL MODULATORS OF TGR5

The present invention comprises compounds of Formula (I). wherein: R1, R2, R3, R4, R5, R6, R7, R8, X, Z1and Z2 are defined in the specification.

Asymmetric Reductive Amination of Cycloalkanones, VII: Asymmetric Synthesis of cis-1R,2R- and cis-1S,2S,-2-Arylcyclohexanamines

The asymmetric synthesis of cis-2-arylcyclohexanamines 4 by a three-step procedure is reported: condensation of racemic 2-arylcyclohexanones 1 with the chiral auxiliary R-(+)- or S-(-)-1-phenylethylamine, respectively, leads to a mixture of the imin isomers 2.Upon hydrogenation with Raney-Nickel just one secondary amin of type 3 is obtained, which is hydrogenolyzed to the optically active primary cis-2-arylcyclohexanamines 4.The relative configuration as well as the conformation were derived from 1H-NMR data.The absolute configuration of the highly enantiomericallypure compounds 4 was determined by CD spectra.