2-(trimethylsilyl)ethyl (2S,3S)-3-tert-butoxycarbonylamino-4-cyclohexyl-2-hydroxybutylcarbamate

Base Information

Chemical Name:2-(trimethylsilyl)ethyl (2S,3S)-3-tert-butoxycarbonylamino-4-cyclohexyl-2-hydroxybutylcarbamate
CAS No.:952685-56-2
Molecular Formula:C₂₁H₄₂N₂O₅Si
Molecular Weight:430.66
Hs Code.:

Synonyms:2-(trimethylsilyl)ethyl (2S,3S)-3-tert-butoxycarbonylamino-4-cyclohexyl-2-hydroxybutylcarbamate

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Chemical Property of 2-(trimethylsilyl)ethyl (2S,3S)-3-tert-butoxycarbonylamino-4-cyclohexyl-2-hydroxybutylcarbamate

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Technology Process of 2-(trimethylsilyl)ethyl (2S,3S)-3-tert-butoxycarbonylamino-4-cyclohexyl-2-hydroxybutylcarbamate

There total 5 articles about 2-(trimethylsilyl)ethyl (2S,3S)-3-tert-butoxycarbonylamino-4-cyclohexyl-2-hydroxybutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 78269-85-9
carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 2-(trimethylsilanyl)-ethyl ester

: tert-butyl (2S,3S)-4-amino-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate

: 952685-56-2
2-(trimethylsilyl)ethyl (2S,3S)-3-tert-butoxycarbonylamino-4-cyclohexyl-2-hydroxybutylcarbamate

Guidance literature:: With potassium carbonate; In water; acetone; at 20 ℃; for 2h;

Reference yield:

: 952685-48-2
tert-butyl (2S,3R)-4-chloro-1-cyclohexyl-3-hydroxybutan-2-ylcarbamate

: 952685-56-2
2-(trimethylsilyl)ethyl (2S,3S)-3-tert-butoxycarbonylamino-4-cyclohexyl-2-hydroxybutylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 1 h

2: ammonium hydroxide / methanol; water / 20 °C

3: potassium carbonate / water; acetone / 2 h / 20 °C

With sodium hydroxide; potassium carbonate; ammonium hydroxide; In methanol; ethanol; water; acetone;

Reference yield:

: 118388-73-1
(S)-2-tert-butyl 1-cyclohexyl-4-diazo-3-oxobutan-2-ylcarbamate

: 952685-56-2
2-(trimethylsilyl)ethyl (2S,3S)-3-tert-butoxycarbonylamino-4-cyclohexyl-2-hydroxybutylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane; diethyl ether / 0 °C

2: sodium tetrahydroborate / tetrahydrofuran; water / 0.75 h / 0 - 20 °C

3: sodium hydroxide / ethanol / 1 h

4: ammonium hydroxide / methanol; water / 20 °C

5: potassium carbonate / water; acetone / 2 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; potassium carbonate; ammonium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; water; acetone;