(6R)-1-<(1R)-2-methoxy-1-phenylethyl>-6-(1-methyl-3-indolyl)-2-piperidone

Base Information

Chemical Name:(6R)-1-<(1R)-2-methoxy-1-phenylethyl>-6-(1-methyl-3-indolyl)-2-piperidone
CAS No.:177748-07-1
Molecular Formula:C₂₃H₂₆N₂O₂
Molecular Weight:362.472
Hs Code.:

Synonyms:(6R)-1-<(1R)-2-methoxy-1-phenylethyl>-6-(1-methyl-3-indolyl)-2-piperidone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6R)-1-<(1R)-2-methoxy-1-phenylethyl>-6-(1-methyl-3-indolyl)-2-piperidone

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Technology Process of (6R)-1-<(1R)-2-methoxy-1-phenylethyl>-6-(1-methyl-3-indolyl)-2-piperidone

There total 1 articles about (6R)-1-<(1R)-2-methoxy-1-phenylethyl>-6-(1-methyl-3-indolyl)-2-piperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 177748-05-9
(R)-1-((R)-2-Hydroxy-1-phenyl-ethyl)-6-(1H-indol-3-yl)-piperidin-2-one

: 74-88-4
methyl iodide

: 177748-07-1
(6R)-1-<(1R)-2-methoxy-1-phenylethyl>-6-(1-methyl-3-indolyl)-2-piperidone

Guidance literature:: With potassium hydroxide; Yield given. Multistep reaction; 1.) DMSO, room temperature, 1.5 h, 2.) DMSO, 2 h;
DOI:10.1021/jo952251+

Reference yield: 60.0%

: 177748-07-1
(6R)-1-<(1R)-2-methoxy-1-phenylethyl>-6-(1-methyl-3-indolyl)-2-piperidone

: 177748-08-2
(2R)-1-((1R)-2-methoxy-1-phenylethyl)-2-(1-methyl-3-indolyl)piperidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 1h; Heating;
DOI:10.1021/jo952251+

Reference yield:

: 177748-07-1
(6R)-1-<(1R)-2-methoxy-1-phenylethyl>-6-(1-methyl-3-indolyl)-2-piperidone

: 3-[(S)-1-((R)-2-Methoxy-1-phenyl-ethyl)-piperidin-2-yl]-1-methyl-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 1 h / Heating

2: ethanol / 24 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1021/jo952251+