3′-O-tert-butyldimethylsilyl-5′-O-(4,4′-dimethoxytrityl)-2′,3′-secouridine

Base Information

Chemical Name:3′-O-tert-butyldimethylsilyl-5′-O-(4,4′-dimethoxytrityl)-2′,3′-secouridine
CAS No.:1120329-63-6
Molecular Formula:C₃₆H₄₆N₂O₈Si
Molecular Weight:662.855
Hs Code.:

Synonyms:3′-O-tert-butyldimethylsilyl-5′-O-(4,4′-dimethoxytrityl)-2′,3′-secouridine

Suppliers and Price of 3′-O-tert-butyldimethylsilyl-5′-O-(4,4′-dimethoxytrityl)-2′,3′-secouridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3′-O-tert-butyldimethylsilyl-5′-O-(4,4′-dimethoxytrityl)-2′,3′-secouridine

Chemical Property:

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Technology Process of 3′-O-tert-butyldimethylsilyl-5′-O-(4,4′-dimethoxytrityl)-2′,3′-secouridine

There total 7 articles about 3′-O-tert-butyldimethylsilyl-5′-O-(4,4′-dimethoxytrityl)-2′,3′-secouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1120329-62-5
C₄₃H₅₀N₂O₉Si

: 1120329-63-6
3′-O-tert-butyldimethylsilyl-5′-O-(4,4′-dimethoxytrityl)-2′,3′-secouridine

Guidance literature:: With water; sodium hydroxide; In methanol; at 0 ℃; for 2.5h;
DOI:10.1021/jo9019978

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 2′-O-benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′,3′-secouridine

: 1120329-63-6
3′-O-tert-butyldimethylsilyl-5′-O-(4,4′-dimethoxytrityl)-2′,3′-secouridine

Guidance literature:: tert-butyldimethylsilyl chloride; 2′-O-benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′,3′-secouridine; With pyridine; at 25 ℃; for 8h;

With pyridine; methanol; sodium hydroxide; at 0 ℃; for 1h;

Reference yield:

: 58-96-8
uridine

: 1120329-63-6
3′-O-tert-butyldimethylsilyl-5′-O-(4,4′-dimethoxytrityl)-2′,3′-secouridine

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / 2 h / 25 °C

2: sodium periodate / 1,4-dioxane / 2 h / 25 °C

3: sodium tetrahydroborate / 1,4-dioxane / 0.3 h / 25 °C

4: Lipozyme TL IM / toluene / 4 h / 25 - 40 °C / Enzymatic reaction

5: pyridine / 19 h / 25 °C

6: sodium hydroxide; water / water / 2.5 h / 0 °C

With pyridine; sodium tetrahydroborate; sodium periodate; Lipozyme TL IM; water; sodium hydroxide; In 1,4-dioxane; water; toluene;