methyl 2-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)-2-methylpropionate

Base Information

Chemical Name:methyl 2-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)-2-methylpropionate
CAS No.:1179906-55-8
Molecular Formula:C₂₅H₂₅F₅N₄O₅
Molecular Weight:556.489
Hs Code.:

methyl 2-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)-2-methylpropionate

Synonyms:methyl 2-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)-2-methylpropionate

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Chemical Property of methyl 2-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)-2-methylpropionate

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Technology Process of methyl 2-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)-2-methylpropionate

There total 6 articles about methyl 2-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1006899-36-0
1-(2-amino-4-fluorobenzyl)-3-(4-fluoro-3-trifluoromethyl-phenyl)-5,5-dimethylimidazolidine-2,4-dione

: 54213-21-7
α-Isocyanatobuttersaeure-methylester

: 1179906-55-8
methyl 2-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)-2-methylpropionate

Guidance literature:: With pyridine; at 20 ℃; for 24h;

Reference yield:

: 70842-04-5
5,5-dimethyl-3-(α,α,α,4-tetrafluoro-m-tolyl)hydantoin

: 1179906-55-8
methyl 2-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)-2-methylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 24 h / 20 °C

2: trimethylamine-borane; methanol / 20 % Pd(OH)2/C / 8 h / 20 °C / Inert atmosphere; Reflux

3: pyridine / 24 h / 20 °C

With pyridine; methanol; trimethylamine-borane; caesium carbonate; 20 % Pd(OH)2/C; In acetonitrile;

Reference yield:

: 76437-44-0
1-(bromomethyl)-4-fluoro-2-nitrobenzene

: 1179906-55-8
methyl 2-(3-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)-2-methylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 24 h / 20 °C

2: trimethylamine-borane; methanol / 20 % Pd(OH)2/C / 8 h / 20 °C / Inert atmosphere; Reflux

3: pyridine / 24 h / 20 °C

With pyridine; methanol; trimethylamine-borane; caesium carbonate; 20 % Pd(OH)2/C; In acetonitrile;