3-cyclohexylidene-2-(pyridin-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol

Base Information

Chemical Name:3-cyclohexylidene-2-(pyridin-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol
CAS No.:1422427-32-4
Molecular Formula:C₂₁H₂₀F₃NO
Molecular Weight:359.391
Hs Code.:

Synonyms:3-cyclohexylidene-2-(pyridin-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol

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Chemical Property of 3-cyclohexylidene-2-(pyridin-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol

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Technology Process of 3-cyclohexylidene-2-(pyridin-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol

There total 4 articles about 3-cyclohexylidene-2-(pyridin-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1422427-09-5
2-((1-methoxycyclohexyl)ethynyl)pyridine

: 1422427-32-4
3-cyclohexylidene-2-(pyridin-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol

Guidance literature:: 2-((1-methoxycyclohexyl)ethynyl)pyridine; With n-butyllithium; zirconocene dichloride; In hexane; toluene; at -78 - 20 ℃; for 3h; Inert atmosphere; Schlenk technique;

4-Trifluoromethylbenzaldehyde; In toluene; at 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

With sodium hydrogencarbonate; In toluene; regioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1021/om301007z

Reference yield:

: 109-04-6
2-bromo-pyridine

: 1422427-32-4
3-cyclohexylidene-2-(pyridin-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / triethylamine / 20 °C / Inert atmosphere; Schlenk technique

2.1: sodium hydride / tetrahydrofuran / 3 - 5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

3.1: zirconocene dichloride; n-butyllithium / toluene; hexane / 3 h / -78 - 20 °C / Inert atmosphere; Schlenk technique

3.2: 2 h / 20 °C / Inert atmosphere; Schlenk technique

3.3: Inert atmosphere; Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; zirconocene dichloride; sodium hydride; In tetrahydrofuran; hexane; triethylamine; toluene;
DOI:10.1021/om301007z

Reference yield:

: 78-27-3
1-Ethynylcyclohexan-1-ol

: 1422427-32-4
3-cyclohexylidene-2-(pyridin-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / triethylamine / 20 °C / Inert atmosphere; Schlenk technique

2.1: sodium hydride / tetrahydrofuran / 3 - 5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

3.1: zirconocene dichloride; n-butyllithium / toluene; hexane / 3 h / -78 - 20 °C / Inert atmosphere; Schlenk technique

3.2: 2 h / 20 °C / Inert atmosphere; Schlenk technique

3.3: Inert atmosphere; Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; zirconocene dichloride; sodium hydride; In tetrahydrofuran; hexane; triethylamine; toluene;
DOI:10.1021/om301007z