1H-Benzimidazole-2-carboxaldehyde,5-chloro-1-methyl-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole-2-carboxaldehyde,5-chloro-1-methyl-(9CI)
• CAS No.: 156212-80-5
• Molecular Formula: C₉H₇ClN₂O
• Molecular Weight: 194.62
• Mol file: 156212-80-5.mol

Synonyms:5-Chloro-1-Methyl-1H-benzimidazole-2-carboxaldehyde

Chemical Property of 1H-Benzimidazole-2-carboxaldehyde,5-chloro-1-methyl-(9CI)

Chemical Property:

• Boiling Point: 367.7±34.0 °C(Predicted)
• PKA: 2.80±0.10(Predicted)
• PSA: 34.89000
• Density: 1.37±0.1 g/cm3(Predicted)
• LogP: 2.03920

Purity/Quality:

99% ，98% ^*data from raw suppliers

5-Chloro-1-methyl-1H-benzo[d]imidazole-2-carbaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole-2-carboxaldehyde,5-chloro-1-methyl-(9CI)

There total 6 articles about 1H-Benzimidazole-2-carboxaldehyde,5-chloro-1-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-chloro-1,2-dimethyl-1H-benzimidazole (26960-04-3) → 5-chloro-1-methyl-1H-benzimidazole-2-carbaldehyde (156212-80-5)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; for 3h; Heating;

Reference yield: 70.0%

(N-methyl-5-chloro-1H-benzimidazole-2-yl)methanol (380177-22-0) → 5-chloro-1-methyl-1H-benzimidazole-2-carbaldehyde (156212-80-5)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 ℃; for 6h;

DOI:10.5012/bkcs.2013.34.4.1272

Reference yield:

4-Chloro-1,2-phenylenediamine (95-83-0) → 5-chloro-1-methyl-1H-benzimidazole-2-carbaldehyde (156212-80-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 4N HCl / 4 h / Heating

2: 44 percent / CH₃ONa / methanol / 4 h / Heating

3: 82 percent / SeO₂ / dioxane / 3 h / Heating

With hydrogenchloride; selenium(IV) oxide; sodium methylate; In 1,4-dioxane; methanol;

upstream raw materials:

5-chloro-1,2-dimethyl-1H-benzimidazole

5-chloro-2-methyl-1H-benzimidazole

4-Chloro-1,2-phenylenediamine

(N-methyl-5-chloro-1H-benzimidazole-2-yl)methanol

Downstream raw materials:

C₂₀H₁₇ClN₂O₃

Refernces

• 1、 Eom, Young Woo,Oh, Sangtae,Woo, Ho Bum,Ham, Jungyeob,Ahn, Chan Mug,Lee, Seokjoon. "Cytotoxicity of substituted benzimidazolyl curcumin mimics against multi-drug resistance cancer cell". . p. 1272 - 1274. Retrieved 2013/07/28.
• 2、 -. "BENZIMIDAZOLYL COMPOUNDS AS POTENTIATORS OF MGLUR2 SUBTYPE OF GLUTAMATE RECEPTOR". Page/Page column 60. . Retrieved 2010/11/30.