1H-Benzimidazole-2-methanol,5-chloro-1-methyl-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole-2-methanol,5-chloro-1-methyl-(9CI)
• CAS No.: 380177-22-0
• Molecular Formula: C₉H₉ClN₂O
• Molecular Weight: 196.636
• Hs Code.: 2933990090
• Mol file: 380177-22-0.mol

Synonyms:(5-Chloro-1-methyl-1H-benzimidazol-2-yl)methanol

Chemical Property of 1H-Benzimidazole-2-methanol,5-chloro-1-methyl-(9CI)

Chemical Property:

• PSA: 38.05000
• LogP: 1.71900
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(5-Chloro-1-methyl-1H-benzo[d]imidazol-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Benzimidazole-2-methanol,5-chloro-1-methyl-(9CI)

There total 4 articles about 1H-Benzimidazole-2-methanol,5-chloro-1-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(5-chloro-1H-benzo [d]imidazol-2-yl)methanol (6953-65-7) + methyl iodide (74-88-4) → (N-methyl-5-chloro-1H-benzimidazole-2-yl)methanol (380177-22-0)

Guidance literature:

With tetrabutylammomium bromide; potassium hydroxide; In tetrahydrofuran; at 0 ℃;

DOI:10.5012/bkcs.2013.34.4.1272

Reference yield: 45.0%

glycolic Acid (79-14-1) + 4-chloro-1-N-methylbenzene-1,2-diamine (59681-66-2) → (N-methyl-5-chloro-1H-benzimidazole-2-yl)methanol (380177-22-0)

Guidance literature:

at 20 - 150 ℃; for 5h;

Reference yield:

4-Chloro-1,2-phenylenediamine (95-83-0) → (N-methyl-5-chloro-1H-benzimidazole-2-yl)methanol (380177-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water / 6 h / Reflux

2: tetrabutylammomium bromide; potassium hydroxide / tetrahydrofuran / 0 °C

With hydrogenchloride; tetrabutylammomium bromide; potassium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/j.bmcl.2011.12.074

upstream raw materials:

4-chloro-N-methyl-2-nitroaniline

glycolic Acid

4-chloro-1-N-methylbenzene-1,2-diamine

4-Chloro-1,2-phenylenediamine

Downstream raw materials:

C₂₀H₁₇ClN₂O₃

C₂₀H₁₇ClN₂O₃

5-chloro-1-methyl-1H-benzimidazole-2-carbaldehyde

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