Ethyl 2-(4-methoxybenzoyl)-3-(3.4-methylenedioxy-phenyl)-4-nitro-butanoate

Base Information

• Chemical Name: Ethyl 2-(4-methoxybenzoyl)-3-(3.4-methylenedioxy-phenyl)-4-nitro-butanoate
• CAS No.: 173864-45-4
• Molecular Formula: C₂₁H₂₁NO₈
• Molecular Weight: 415.4
• Mol file: 173864-45-4.mol

Synonyms:Ethyl 2-(4-methoxybenzoyl)-3-(3.4-methylenedioxy-phenyl)-4-nitro-butanoate

Chemical Property of Ethyl 2-(4-methoxybenzoyl)-3-(3.4-methylenedioxy-phenyl)-4-nitro-butanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Ethyl 2-(4-methoxybenzoyl)-3-(3.4-methylenedioxy-phenyl)-4-nitro-butanoate

There total 5 articles about Ethyl 2-(4-methoxybenzoyl)-3-(3.4-methylenedioxy-phenyl)-4-nitro-butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5-((E)-2-nitroethenyl)-1,3-benzodioxole (1485-00-3,22568-48-5) + ethyl 4-methoxybenzoylacetate (2881-83-6) → Ethyl 2-(4-methoxybenzoyl)-3-(3.4-methylenedioxy-phenyl)-4-nitro-butanoate (173864-45-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; isopropyl alcohol; for 4h; Ambient temperature;

DOI:10.1021/jm9505369

Reference yield:

5-((E)-2-nitroethenyl)-1,3-benzodioxole (1485-00-3,22568-48-5) + ethyl 4-methoxybenzoylacetate (2881-83-6) → 3-Benzo[1,3]dioxol-5-yl-2-[1-hydroxy-1-(4-methoxy-phenyl)-meth-(E)-ylidene]-4-nitro-butyric acid ethyl ester + Ethyl 2-(4-methoxybenzoyl)-3-(3.4-methylenedioxy-phenyl)-4-nitro-butanoate (173864-45-4)

Guidance literature:

With 4-methyl-morpholine; magnesium triflate; {3aS-[2(3'aR*,8'aS*),3aα,8aα]}-2,2'-(cyclopropylidene)-bis{3a,8a-dihydro-8H-indeno[1,2-d]-oxazole}; In chloroform; at 20 ℃; Title compound not separated from byproducts.;

DOI:10.1021/ja026788y

Reference yield:

5-((E)-2-nitroethenyl)-1,3-benzodioxole (1485-00-3,22568-48-5) + 1,8-diazabicyclo[5.4.0]undec-7-ene (6674-22-2,83329-50-4) + ethyl 4-methoxybenzoylacetate (2881-83-6) → Ethyl 2-(4-methoxybenzoyl)-3-(3.4-methylenedioxy-phenyl)-4-nitro-butanoate (173864-45-4)

Guidance literature:

In ethyl acetate;

upstream raw materials:

5-((E)-2-nitroethenyl)-1,3-benzodioxole

ethyl 4-methoxybenzoylacetate

piperonal

1-(4-methoxyphenyl)ethanone