ethyl α-<<3-<2-(1,1-dimethylethoxy)-2-oxoethoxy>phenyl>methyl>-4,5-diphenyl-α-(2-propenyl)-2-oxazoleacetate

Base Information

Chemical Name:ethyl α-<<3-<2-(1,1-dimethylethoxy)-2-oxoethoxy>phenyl>methyl>-4,5-diphenyl-α-(2-propenyl)-2-oxazoleacetate
CAS No.:152495-13-1
Molecular Formula:C₃₅H₃₇NO₆
Molecular Weight:567.682
Hs Code.:

Synonyms:ethyl α-<<3-<2-(1,1-dimethylethoxy)-2-oxoethoxy>phenyl>methyl>-4,5-diphenyl-α-(2-propenyl)-2-oxazoleacetate

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Chemical Property of ethyl α-<<3-<2-(1,1-dimethylethoxy)-2-oxoethoxy>phenyl>methyl>-4,5-diphenyl-α-(2-propenyl)-2-oxazoleacetate

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Technology Process of ethyl α-<<3-<2-(1,1-dimethylethoxy)-2-oxoethoxy>phenyl>methyl>-4,5-diphenyl-α-(2-propenyl)-2-oxazoleacetate

There total 6 articles about ethyl α-<<3-<2-(1,1-dimethylethoxy)-2-oxoethoxy>phenyl>methyl>-4,5-diphenyl-α-(2-propenyl)-2-oxazoleacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 106-95-6
allyl bromide

: 147593-93-9
ethyl α-<<3-<<(1,1-dimethylethoxy)carbonyl>methoxy>phenyl>methyl>-4,5-diphenyl-2-oxazoleacetate

: 152495-13-1
ethyl α-<<3-<2-(1,1-dimethylethoxy)-2-oxoethoxy>phenyl>methyl>-4,5-diphenyl-α-(2-propenyl)-2-oxazoleacetate

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; for 0.25h; Ambient temperature;
DOI:10.1021/jm00076a017

Reference yield:

: 26820-93-9
ethyl 4,5-diphenyl-2-oxazoleacetate

: 152495-13-1
ethyl α-<<3-<2-(1,1-dimethylethoxy)-2-oxoethoxy>phenyl>methyl>-4,5-diphenyl-α-(2-propenyl)-2-oxazoleacetate

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine, p-TsOH / toluene / 18 h / Heating

2: 48 percent / H₂ / 10percent Pd/C / ethyl acetate / 1551.4 Torr

3: 72 percent / K₂CO₃, 18-crown-6 / tetrahydrofuran / 0.25 h / Ambient temperature

With piperidine; 18-crown-6 ether; hydrogen; potassium carbonate; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1021/jm00076a017

Reference yield:

: 119-53-9,579-44-2
2-hydroxy-2-phenylacetophenone

: 152495-13-1
ethyl α-<<3-<2-(1,1-dimethylethoxy)-2-oxoethoxy>phenyl>methyl>-4,5-diphenyl-α-(2-propenyl)-2-oxazoleacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 4-(dimethylamino)pyridine, pyridine, 2.) AcOH, NH₄OAc / 1.) CH₂Cl₂, a) 10 deg C, 30 min, b) RT, 2 h, 2.) reflux, 2 h

2: piperidine, p-TsOH / toluene / 18 h / Heating

3: 48 percent / H₂ / 10percent Pd/C / ethyl acetate / 1551.4 Torr

4: 72 percent / K₂CO₃, 18-crown-6 / tetrahydrofuran / 0.25 h / Ambient temperature

With piperidine; pyridine; dmap; 18-crown-6 ether; ammonium acetate; hydrogen; potassium carbonate; toluene-4-sulfonic acid; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1021/jm00076a017