{4-[5-(4-fluorobenzyl)furan-2-yl]-4-oxobutyl}carbamic acid tert-butylester

Base Information

• Chemical Name: {4-[5-(4-fluorobenzyl)furan-2-yl]-4-oxobutyl}carbamic acid tert-butylester
• CAS No.: 500371-92-6
• Molecular Formula: C₂₀H₂₄FNO₄
• Molecular Weight: 361.413
• Mol file: 500371-92-6.mol

Synonyms:{4-[5-(4-fluorobenzyl)furan-2-yl]-4-oxobutyl}carbamic acid tert-butylester

Chemical Property of {4-[5-(4-fluorobenzyl)furan-2-yl]-4-oxobutyl}carbamic acid tert-butylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of {4-[5-(4-fluorobenzyl)furan-2-yl]-4-oxobutyl}carbamic acid tert-butylester

There total 1 articles about {4-[5-(4-fluorobenzyl)furan-2-yl]-4-oxobutyl}carbamic acid tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Bromo-5-(4-fluorophenylmethyl)furan (154355-81-4) + tert-butyl 2-oxopyrrolidine-1-carboxylate (85909-08-6) → {4-[5-(4-fluorobenzyl)furan-2-yl]-4-oxobutyl}carbamic acid tert-butylester (500371-92-6)

Guidance literature:

2-Bromo-5-(4-fluorophenylmethyl)furan; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

tert-butyl 2-oxopyrrolidine-1-carboxylate; In tetrahydrofuran; for 2h;

With ammonium chloride; water; In tetrahydrofuran;

Reference yield:

Dimethyl oxalate (553-90-2) + {4-[5-(4-fluorobenzyl)furan-2-yl]-4-oxobutyl}carbamic acid tert-butylester (500371-92-6) → 3-(4-fluorophenyl)-2-hydroxy-3-[5-(5-hydroxy-6-oxo-1,2,3,6-tetrahydropyridine-4-carbonyl)furan-2-yl]propenoic acid methyl ester

Guidance literature:

Dimethyl oxalate; {4-[5-(4-fluorobenzyl)furan-2-yl]-4-oxobutyl}carbamic acid tert-butylester; With sodium ethanolate; In methanol; toluene; at 20 ℃; for 4h;

With hydrogenchloride; In methanol; water; toluene;

upstream raw materials:

2-Bromo-5-(4-fluorophenylmethyl)furan

tert-butyl 2-oxopyrrolidine-1-carboxylate

Refernces