154355-81-4

Upstream product

• 154355-80-3 2-(4-Fluorophenylmethyl)furan 
• 500365-83-3 (5-bromofuran-2-yl)-(4-fluorophenyl)methanone 

Downstream Products

• 500371-87-9 4-benzyloxy-1-benzyloxymethyl-5-[5-(4-fluorobenzyl)furan-2-carbonyl]-2-methyl-1,2-dihydropyrazole-3-one 
• 500365-58-2 4-[5-(4-fluorobenzyl)furan-2-carbonyl]-1-isopropyl-3-methoxy-1,5-dihydropyrrole-2-one 
• 500365-63-9 {3-[5-(4-fluorobenzyl)furan-2-yl]-3-oxopropyl}methylcarbamic acid tert-butyl ester 
• 457949-07-4 C₂₀H₁₄FNO₄ 
• 500370-38-7 C₁₄H₁₇FOSn 
• 500371-92-6 {4-[5-(4-fluorobenzyl)furan-2-yl]-4-oxobutyl}carbamic acid tert-butylester 
• 500365-71-9 cyclopropyl{3-[5-(4-fluorobenzyl)furan-2-yl]-3-oxopropyl}carbamic acid tert-butyl ester 
• 500372-06-5 (4,5-dimethoxy-6-methylpyridin-3-yl)-[5-(4-fluorobenzyl)furan-2-yl]methanone 
• 500371-74-4 3-benzyloxy-5-bromo-2-[5-(4-fluorobenzyl)furan2-carbonyl]pyrane-4-one 
• 500371-97-1 4-[5-(4-fluorobenzyl)furan-2-carbonyl]-3-methoxymethoxy-1-methoxymethyl-1H-pyridine-2-one 
• 500372-02-1 (3,4-dimethoxypyridine-2-yl)-[5-(4-fluorobenzyl)furan-2-yl]methanone 
• 857665-35-1 C₂₄H₁₈BrFN₂O₄ 

Relevant academic research and scientific papers

ANTIVIRAL AGENT

The present invention provides an integrase inhibitor. The inventors have have found the following compound of formula (I) possessing an integrase inhibitory activity. (wherein, R C and R D taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxy, mercapto or amino; Z is O, S or NH ; R A is a group shown by (wherein, C ring is N-containing aromatic heterocycle) or the like)

Substituted arylalkynyl-and heteroarylalkynl-N-hydroxyurea inhibitors of leukotriene biosynthesis

The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More particularly, this invention concerns certain substituted arylalkynyl- and ((heteroaryl)alkynyl)-N-hydroxy-ureas which inhibit leukotriene biosynthesis, to pharmaceutical compositions of these compounds and to a method of inhibiting leukotriene biosynthesis.

[(SUBSTITUTED) PHENYALKYL]FURYLALKYNYL-AND [SUBSTITUTED)PHENYALKYL]THIENYLALKYNYL-N-HYDROXYUREA INHIBITORS OR LEUKOTRIENE BIOSYNTHESIS

The present invention relates to compounds of the formula and the pharmaceutically acceptable salts thereof wherein Z is selected from optionally substituted phenyl, furyl, thienyl or thiazolyl; which inhibits leukotriene biosynthesis and is useful in the treatment of inflammatory disease states; also disclosed are leukotriene biosynthesis inhibiting compositions and a method for inhibiting 5-lipoxygenase activity and leukotriene biosynthesis