ethyl 2-oxo-1-(3-phenylprop-2-yn-1-yl)cyclohexanecarboxylate

Base Information

• Chemical Name: ethyl 2-oxo-1-(3-phenylprop-2-yn-1-yl)cyclohexanecarboxylate
• CAS No.: 1000992-73-3
• Molecular Formula: C₁₈H₂₀O₃
• Molecular Weight: 284.355
• Mol file: 1000992-73-3.mol

Synonyms:ethyl 2-oxo-1-(3-phenylprop-2-yn-1-yl)cyclohexanecarboxylate

Chemical Property of ethyl 2-oxo-1-(3-phenylprop-2-yn-1-yl)cyclohexanecarboxylate

Chemical Property:

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Technology Process of ethyl 2-oxo-1-(3-phenylprop-2-yn-1-yl)cyclohexanecarboxylate

There total 1 articles about ethyl 2-oxo-1-(3-phenylprop-2-yn-1-yl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

bromobenzene (108-86-1,52753-63-6) + 2-oxo-1-prop-2-ynyl-cyclohexanecarboxylic acid ethyl ester (56576-36-4) → ethyl 2-oxo-1-(3-phenylprop-2-yn-1-yl)cyclohexanecarboxylate (1000992-73-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In dimethyl sulfoxide; at 90 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c5cc05926g

Reference yield: 86.0%

ethyl 2-oxo-1-(3-phenylprop-2-yn-1-yl)cyclohexanecarboxylate (1000992-73-3) → ethyl 9-oxo-4-phenylbicyclo[3.3.1]non-3-ene-1-carboxylate

Guidance literature:

With silver trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 90 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c5cc05926g

Reference yield: 76.0%

ethyl 2-oxo-1-(3-phenylprop-2-yn-1-yl)cyclohexanecarboxylate (1000992-73-3) + N-methoxybenzamide (2446-51-7) → C25H25NO4

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; sodium acetate; In methanol; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c6sc01456a

upstream raw materials:

bromobenzene

2-oxo-1-prop-2-ynyl-cyclohexanecarboxylic acid ethyl ester

Refernces