methyl 6-(chloromethyl)-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate

Base Information

• Chemical Name: methyl 6-(chloromethyl)-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate
• CAS No.: 74614-99-6
• Molecular Formula: C₂₄H₂₄ClNO₅
• Molecular Weight: 441.911
• Mol file: 74614-99-6.mol

Synonyms:methyl 6-(chloromethyl)-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate

Chemical Property of methyl 6-(chloromethyl)-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 6-(chloromethyl)-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate

There total 11 articles about methyl 6-(chloromethyl)-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate (74614-98-5) → methyl 6-(chloromethyl)-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate (74614-99-6)

Guidance literature:

With thionyl chloride; In benzene; for 1.5h; Ambient temperature;

DOI:10.1021/ja00366a028

Reference yield:

methyl 6-<(acetyloxy)methyl>-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate (74614-97-4) → methyl 6-(chloromethyl)-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate (74614-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

2: 100 percent / thionyl chloride / benzene / 1.5 h / Ambient temperature

With thionyl chloride; potassium carbonate; In methanol; benzene;

DOI:10.1021/ja00366a028

Reference yield:

methyl 4-<3,4-dimethoxy-2-(9phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate 1-oxide → methyl 6-(chloromethyl)-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate (74614-99-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / 2 h / 120 °C

2: 100 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

3: 100 percent / thionyl chloride / benzene / 1.5 h / Ambient temperature

With thionyl chloride; potassium carbonate; In methanol; benzene;

DOI:10.1021/ja00366a028

upstream raw materials:

methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate

methyl 6-<(acetyloxy)methyl>-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3-methyl-2-pyridinecarboxylate

methyl 4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-3,6-dimethyl-2-pyridinecarboxylate

3,4-dimethoxy-(phenylmethoxy)benzaldehyde

Downstream raw materials:

1-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-6-methoxycarbonyl-5-methyl-pyridin-2-ylmethyl]-1-cyanomethyl-pyrrolidinium; chloride

methyl 4<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-5-formyl-3,6-dimethyl-2-pyridinecarboxylate

methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-formyl-3-methyl-2-pyridinecarboxylate

methyl 5-amino-4-<3,4-dimethoxy-2-(phenylmethoxy)phenyl>-6-(hydroxymethyl)-3-methyl-2-pyridinecarboxylate