trans-2,2-dimethyl-3-phenyl-4--7-methoxychroman hydrochloride

Base Information

Chemical Name:trans-2,2-dimethyl-3-phenyl-4--7-methoxychroman hydrochloride
CAS No.:84394-11-6
Molecular Formula:C₃₀H₃₅NO₃*ClH
Molecular Weight:494.074
Hs Code.:

trans-2,2-dimethyl-3-phenyl-4-<o-(β-pyrrolidinoethoxy)phenyl>-7-methoxychroman hydrochloride

Synonyms:trans-2,2-dimethyl-3-phenyl-4--7-methoxychroman hydrochloride

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Chemical Property of trans-2,2-dimethyl-3-phenyl-4--7-methoxychroman hydrochloride

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Technology Process of trans-2,2-dimethyl-3-phenyl-4--7-methoxychroman hydrochloride

There total 4 articles about trans-2,2-dimethyl-3-phenyl-4--7-methoxychroman hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 84394-31-0
1-{2-[2-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-phenoxy]-ethyl}-pyrrolidine

: 84394-11-6
trans-2,2-dimethyl-3-phenyl-4--7-methoxychroman hydrochloride

Guidance literature:: With n-butyllithium; In hexane; dimethyl sulfoxide; for 16h; Ambient temperature;
DOI:10.1021/jm00358a026

Reference yield:

: 84394-18-3
4-(2-hydroxyphenyl)-7-methoxy-2,2-dimethyl-3-phenylchromene

: 84394-11-6
trans-2,2-dimethyl-3-phenyl-4--7-methoxychroman hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / H₂ / 10percent Pd/C / methanol / 8 h / 3102.9 Torr

2: K₂CO₃ / acetone / 14 h / Heating

3: 90 percent / n-BuLi / hexane; dimethylsulfoxide / 16 h / Ambient temperature

With n-butyllithium; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; hexane; dimethyl sulfoxide; acetone;
DOI:10.1021/jm00358a026

Reference yield:

: 7250-67-1
1-(2-chloroethyl)pyrrolidine hydrochloride

: 84394-11-6
trans-2,2-dimethyl-3-phenyl-4--7-methoxychroman hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / acetone / 14 h / Heating

2: 90 percent / n-BuLi / hexane; dimethylsulfoxide / 16 h / Ambient temperature

With n-butyllithium; potassium carbonate; In hexane; dimethyl sulfoxide; acetone;
DOI:10.1021/jm00358a026