8-benzyl-6-ethoxycarbonyl-4,4-bis(4-fluorophenyl)-1-hydroxy-8-aza-2,3-dioxabicyclo<4.3.0>nonan-9-one

Base Information

Chemical Name:8-benzyl-6-ethoxycarbonyl-4,4-bis(4-fluorophenyl)-1-hydroxy-8-aza-2,3-dioxabicyclo<4.3.0>nonan-9-one
CAS No.:206754-67-8
Molecular Formula:C₂₈H₂₅F₂NO₆
Molecular Weight:509.506
Hs Code.:

Synonyms:8-benzyl-6-ethoxycarbonyl-4,4-bis(4-fluorophenyl)-1-hydroxy-8-aza-2,3-dioxabicyclo<4.3.0>nonan-9-one

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Chemical Property of 8-benzyl-6-ethoxycarbonyl-4,4-bis(4-fluorophenyl)-1-hydroxy-8-aza-2,3-dioxabicyclo<4.3.0>nonan-9-one

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Technology Process of 8-benzyl-6-ethoxycarbonyl-4,4-bis(4-fluorophenyl)-1-hydroxy-8-aza-2,3-dioxabicyclo<4.3.0>nonan-9-one

There total 2 articles about 8-benzyl-6-ethoxycarbonyl-4,4-bis(4-fluorophenyl)-1-hydroxy-8-aza-2,3-dioxabicyclo<4.3.0>nonan-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 6175-14-0
1,1-bis-(4-fluorophenyl)ethene

: 4450-98-0
ethyl 1-benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate

: 206754-67-8
8-benzyl-6-ethoxycarbonyl-4,4-bis(4-fluorophenyl)-1-hydroxy-8-aza-2,3-dioxabicyclo<4.3.0>nonan-9-one

Guidance literature:: With oxygen; manganese triacetate; In acetic acid; at 23 ℃; for 16h;

Reference yield:

: 23583-21-3
ethyl-3-benzylamino propionate

: 206754-67-8
8-benzyl-6-ethoxycarbonyl-4,4-bis(4-fluorophenyl)-1-hydroxy-8-aza-2,3-dioxabicyclo<4.3.0>nonan-9-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium ethoxide

2: 61 percent / Mn(OAc)3*2H₂O, O₂ (air) / acetic acid / 16 h / 23 °C

With oxygen; sodium ethanolate; manganese triacetate; In acetic acid;

Reference yield: 97.0%

: 206754-67-8
8-benzyl-6-ethoxycarbonyl-4,4-bis(4-fluorophenyl)-1-hydroxy-8-aza-2,3-dioxabicyclo<4.3.0>nonan-9-one

: (3aR,6aS)-5-Benzyl-2,2-bis-(4-fluoro-phenyl)-6a-hydroxy-6-oxo-hexahydro-furo[2,3-c]pyrrole-3a-carboxylic acid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; dichloromethane; at 40 ℃; for 1.5h; under 38000 Torr;
DOI:10.1016/S0040-4039(99)00604-8