N-(4-amino-[1,1'-biphenyl]-3-yl)-8-cyclopropyl-7-(piperazin-1-yl)isoquinoline-3-carboxamide

Base Information

Chemical Name:N-(4-amino-[1,1'-biphenyl]-3-yl)-8-cyclopropyl-7-(piperazin-1-yl)isoquinoline-3-carboxamide
CAS No.:1609389-55-0
Molecular Formula:C₂₉H₂₉N₅O
Molecular Weight:463.582
Hs Code.:

Synonyms:N-(4-amino-[1,1'-biphenyl]-3-yl)-8-cyclopropyl-7-(piperazin-1-yl)isoquinoline-3-carboxamide

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Chemical Property of N-(4-amino-[1,1'-biphenyl]-3-yl)-8-cyclopropyl-7-(piperazin-1-yl)isoquinoline-3-carboxamide

Chemical Property:

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Technology Process of N-(4-amino-[1,1'-biphenyl]-3-yl)-8-cyclopropyl-7-(piperazin-1-yl)isoquinoline-3-carboxamide

There total 6 articles about N-(4-amino-[1,1'-biphenyl]-3-yl)-8-cyclopropyl-7-(piperazin-1-yl)isoquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1609390-80-8
C₃₉H₄₅N₅O₅

: 1609389-55-0
N-(4-amino-[1,1'-biphenyl]-3-yl)-8-cyclopropyl-7-(piperazin-1-yl)isoquinoline-3-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1609390-77-3
ethyl 8-bromo-7-(4-(tert-butoxycarbonyl)piperazin-1-yl)isoquinoline-3-carboxylate

: 1609389-55-0
N-(4-amino-[1,1'-biphenyl]-3-yl)-8-cyclopropyl-7-(piperazin-1-yl)isoquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: palladium diacetate; tricyclohexylphosphine; potassium phosphate / water; toluene / 100 °C / Inert atmosphere

2: sodium hydroxide / tetrahydrofuran; ethanol / 3 h / 60 °C

3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 55 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With potassium phosphate; 1-hydroxy-7-aza-benzotriazole; palladium diacetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1609390-76-2
ethyl 7-(4-(tert-butoxycarbonyl)piperazin-1-yl)isoquinoline-3-carboxylate

: 1609389-55-0
N-(4-amino-[1,1'-biphenyl]-3-yl)-8-cyclopropyl-7-(piperazin-1-yl)isoquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / dichloromethane / 1 h / 0 °C

2: palladium diacetate; tricyclohexylphosphine; potassium phosphate / water; toluene / 100 °C / Inert atmosphere

3: sodium hydroxide / tetrahydrofuran; ethanol / 3 h / 60 °C

4: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 55 °C

5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With potassium phosphate; N-Bromosuccinimide; 1-hydroxy-7-aza-benzotriazole; palladium diacetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;