(2S,5S)-2,5-bis-tert-butoxycarbonylaminohexane-1,6-dioic acid dimethyl ester

Base Information

• Chemical Name: (2S,5S)-2,5-bis-tert-butoxycarbonylaminohexane-1,6-dioic acid dimethyl ester
• CAS No.: 915040-50-5
• Molecular Formula: C₁₈H₃₂N₂O₈
• Molecular Weight: 404.461
• Mol file: 915040-50-5.mol

Synonyms:(2S,5S)-2,5-bis-tert-butoxycarbonylaminohexane-1,6-dioic acid dimethyl ester

Chemical Property of (2S,5S)-2,5-bis-tert-butoxycarbonylaminohexane-1,6-dioic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of (2S,5S)-2,5-bis-tert-butoxycarbonylaminohexane-1,6-dioic acid dimethyl ester

There total 19 articles about (2S,5S)-2,5-bis-tert-butoxycarbonylaminohexane-1,6-dioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-Chloro-4-iodobenzene (637-87-6) + N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester (93267-04-0,170848-34-7,889670-02-4) → (2S,5S)-2,5-bis-tert-butoxycarbonylaminohexane-1,6-dioic acid dimethyl ester (915040-50-5) + (S)-methyl 2-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)propanoate

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; dichloro bis((p-dimethylaminophenyl)-?-di-tert-butylphosphine)palladium(II); zinc; In water; at 65 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jo102334c

Reference yield: 72.0%

4-fluoro-1-iodobenzene (352-34-1) + N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester (93267-04-0,170848-34-7,889670-02-4) → (2S,5S)-2,5-bis-tert-butoxycarbonylaminohexane-1,6-dioic acid dimethyl ester (915040-50-5) + methyl 2-(S)-((tert-butoxycarbonyl)amino)-3-(4'-fluorophenyl)propanoate (134362-34-8,86129-35-3)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; dichloro bis((p-dimethylaminophenyl)-?-di-tert-butylphosphine)palladium(II); zinc; In water; at 65 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jo102334c

Reference yield: 67.0%

iodobenzene (591-50-4) + N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester (93267-04-0,170848-34-7,889670-02-4) → (2S,5S)-2,5-bis-tert-butoxycarbonylaminohexane-1,6-dioic acid dimethyl ester (915040-50-5) + (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester (51987-73-6)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; dichloro bis((p-dimethylaminophenyl)-?-di-tert-butylphosphine)palladium(II); zinc; In water; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jo102334c

upstream raw materials:

bromobenzene

N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester

iodobenzene

ortho-methylphenyl iodide