6-bromo-3-(4-bromophenyl)-1-methylisoquinoline

Base Information

• Chemical Name: 6-bromo-3-(4-bromophenyl)-1-methylisoquinoline
• CAS No.: 1619224-94-0
• Molecular Formula: C₁₆H₁₁Br₂N
• Molecular Weight: 377.078
• Mol file: 1619224-94-0.mol

Synonyms:6-bromo-3-(4-bromophenyl)-1-methylisoquinoline

Chemical Property of 6-bromo-3-(4-bromophenyl)-1-methylisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromo-3-(4-bromophenyl)-1-methylisoquinoline

There total 3 articles about 6-bromo-3-(4-bromophenyl)-1-methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-(4-bromophenyl)ethan-1-one O-pivaloyl oxime (1570194-60-3) → 6-bromo-3-(4-bromophenyl)-1-methylisoquinoline (1619224-94-0)

Guidance literature:

With palladium diacetate; In toluene; at 150 ℃; for 36h; regioselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1021/jo5010586

Reference yield: 49.0%

p-bromoacetophenone oxime (59862-55-4,73744-33-9,5798-71-0) → 6-bromo-3-(4-bromophenyl)-1-methylisoquinoline (1619224-94-0)

Guidance literature:

With palladium diacetate; In acetonitrile; at 130 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.joc.5b02376

Reference yield:

para-bromoacetophenone (99-90-1) → 6-bromo-3-(4-bromophenyl)-1-methylisoquinoline (1619224-94-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; potassium acetate / methanol / 0.67 h / Reflux

2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

3: palladium diacetate / toluene / 36 h / 150 °C / Sealed tube; Inert atmosphere

With hydroxylamine hydrochloride; potassium acetate; palladium diacetate; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1021/jo5010586

upstream raw materials:

para-bromoacetophenone

1-(4-bromophenyl)ethan-1-one O-pivaloyl oxime

p-bromoacetophenone oxime