3'-dephenyl-3'-(2-methylprop-1-enyl)-7-(3-methyldisulfanylpropanoyl)-10-propanoyl-2'-triisopropylsilyldocetaxel

Base Information

Chemical Name:3'-dephenyl-3'-(2-methylprop-1-enyl)-7-(3-methyldisulfanylpropanoyl)-10-propanoyl-2'-triisopropylsilyldocetaxel
CAS No.:485801-35-2
Molecular Formula:C₅₇H₈₅NO₁₆S₂Si
Molecular Weight:1132.52
Hs Code.:

Synonyms:3'-dephenyl-3'-(2-methylprop-1-enyl)-7-(3-methyldisulfanylpropanoyl)-10-propanoyl-2'-triisopropylsilyldocetaxel

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Chemical Property of 3'-dephenyl-3'-(2-methylprop-1-enyl)-7-(3-methyldisulfanylpropanoyl)-10-propanoyl-2'-triisopropylsilyldocetaxel

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Technology Process of 3'-dephenyl-3'-(2-methylprop-1-enyl)-7-(3-methyldisulfanylpropanoyl)-10-propanoyl-2'-triisopropylsilyldocetaxel

There total 2 articles about 3'-dephenyl-3'-(2-methylprop-1-enyl)-7-(3-methyldisulfanylpropanoyl)-10-propanoyl-2'-triisopropylsilyldocetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 138148-59-1
3-Methyldisulfanyl-propionic acid

: 485801-50-1
3'-dephenyl-3'-(2-methylprop-1-enyl)-10-propanoyl-2'-triisopropylsilyldocetaxel

: 485801-35-2
3'-dephenyl-3'-(2-methylprop-1-enyl)-7-(3-methyldisulfanylpropanoyl)-10-propanoyl-2'-triisopropylsilyldocetaxel

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In dichloromethane; for 2h;
DOI:10.1021/jm025540g

Reference yield:

: 178250-16-3
C₅₉H₉₃NO₁₅Si₂

: 485801-35-2
3'-dephenyl-3'-(2-methylprop-1-enyl)-7-(3-methyldisulfanylpropanoyl)-10-propanoyl-2'-triisopropylsilyldocetaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / aq. HCl / ethanol / 16 h / 20 °C

2: 89 percent / EDC hydrochloride / DMAP / CH₂Cl₂ / 2 h

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In ethanol; dichloromethane;
DOI:10.1021/jm025540g