N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycyl-N-methyl-L-leucylglycinol

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycyl-N-methyl-L-leucylglycinol
CAS No.:112550-37-5
Molecular Formula:C₂₈H₄₅N₅O₈
Molecular Weight:579.694
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycyl-N-methyl-L-leucylglycinol

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Chemical Property of N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycyl-N-methyl-L-leucylglycinol

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Technology Process of N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycyl-N-methyl-L-leucylglycinol

There total 5 articles about N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycyl-N-methyl-L-leucylglycinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 141-43-5
ethanolamine

: 112550-36-4
N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycyl-N-methyl-L-leucylglycinol

: 112550-37-5
N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycyl-N-methyl-L-leucylglycinol

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; 0 deg C, 1 h -> room temperature, 20 h;
DOI:10.1021/jm00397a019

Reference yield:

: 48168-99-6
N-methyl-L-leucine benzyl ester

: 112550-37-5
N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycyl-N-methyl-L-leucylglycinol

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / Et₃N, HOBT, DCC / tetrahydrofuran; CHCl₃ / 0 deg C, 1 h -> room temperature

2: 85 percent / aq. NaOH / methanol / 0 deg C, 1 h -> room temperature

3: 50 percent / HOBT, DCC / tetrahydrofuran; CHCl₃ / 0 deg C, 1 h -> room temperature, 20 h

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jm00397a019

Reference yield:

: 64410-47-5,79225-08-4
N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycine

: 112550-37-5
N-(tert-butyloxycarbonyl)-L-tyrosyl-D-alanylglycyl-N-methyl-L-leucylglycinol

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / Et₃N, HOBT, DCC / tetrahydrofuran; CHCl₃ / 0 deg C, 1 h -> room temperature

2: 85 percent / aq. NaOH / methanol / 0 deg C, 1 h -> room temperature

3: 50 percent / HOBT, DCC / tetrahydrofuran; CHCl₃ / 0 deg C, 1 h -> room temperature, 20 h

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jm00397a019