methyl 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoate

Base Information

Chemical Name:methyl 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoate
CAS No.:1300747-97-0
Molecular Formula:C₂₃H₂₁FN₄O₃S₂
Molecular Weight:484.575
Hs Code.:

Synonyms:methyl 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoate

Suppliers and Price of methyl 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoate

There total 6 articles about methyl 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 399-74-6
2-chloro-6-fluorobenzothiazole

: 1300747-69-6
methyl 2-(4-(4-aminophenyl)thiazole-2-carboxamido)-3-methylbutanoate

: 1300747-97-0
methyl 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoate

Guidance literature:: With hydrogenchloride; In water; butan-1-ol; at 70 - 90 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.05.006

Reference yield:

: 1300747-70-9
methyl 3-methyl-2-(4-(4-nitrophenyl)thiazole-2-carboxamido)butanoate

: 1300747-97-0
methyl 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum (III) chloride; iron / ethanol; water / 3 h / 80 - 85 °C / Inert atmosphere

2: hydrogenchloride / water; butan-1-ol / 16 h / 70 - 90 °C / Inert atmosphere

With hydrogenchloride; aluminum (III) chloride; iron; In ethanol; water; butan-1-ol;
DOI:10.1016/j.ejmech.2013.05.006

Reference yield:

: 53101-04-5
ethyl 4-(4-nitrophenyl)-1,3-thiazole-2-carboxylate

: 1300747-97-0
methyl 2-(4-(4-((6-fluorobenzo[d]thiazol-2-yl)amino)phenyl)thiazole-2-carboxamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.33 h / -20 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

3.1: aluminum (III) chloride; iron / ethanol; water / 3 h / 80 - 85 °C / Inert atmosphere

4.1: hydrogenchloride / water; butan-1-ol / 16 h / 70 - 90 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; aluminum (III) chloride; water; iron; lithium hydroxide; isobutyl chloroformate; In tetrahydrofuran; ethanol; water; butan-1-ol;
DOI:10.1016/j.ejmech.2013.05.006