thiophosphoric acid O,O'-diethyl ester S-(4-fluorophenyl) ester

Base Information

• Chemical Name: thiophosphoric acid O,O'-diethyl ester S-(4-fluorophenyl) ester
• CAS No.: 333-42-6
• Molecular Formula: C₁₀H₁₄FO₃PS
• Molecular Weight: 264.258
• Mol file: 333-42-6.mol

Synonyms:thiophosphoric acid O,O'-diethyl ester S-(4-fluorophenyl) ester

Chemical Property of thiophosphoric acid O,O'-diethyl ester S-(4-fluorophenyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of thiophosphoric acid O,O'-diethyl ester S-(4-fluorophenyl) ester

There total 12 articles about thiophosphoric acid O,O'-diethyl ester S-(4-fluorophenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

bis(4-fluorophenyl)disulfide (405-31-2) + triethyl phosphite (122-52-1) → thiophosphoric acid O,O'-diethyl ester S-(4-fluorophenyl) ester (333-42-6)

Guidance literature:

With air; In acetonitrile; at 20 ℃; for 8h; Green chemistry;

Reference yield: 94.0%

4-Fluorothiophenol (371-42-6) + triethyl phosphite (122-52-1) → thiophosphoric acid O,O'-diethyl ester S-(4-fluorophenyl) ester (333-42-6)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

DOI:10.1039/c7ra09057a

Reference yield: 94.0%

4-fluorobenzenediazonium tetrafluoroborate (459-45-0) + phosphonic acid diethyl ester (762-04-9) → thiophosphoric acid O,O'-diethyl ester S-(4-fluorophenyl) ester (333-42-6)

Guidance literature:

phosphonic acid diethyl ester; With copper(II) bis(trifluoromethanesulfonate); sulfur; triethylamine; In acetonitrile; at 20 ℃; for 0.333333h; Schlenk technique; Inert atmosphere; Green chemistry;

4-fluorobenzenediazonium tetrafluoroborate; In acetonitrile; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere; Green chemistry;

DOI:10.1021/acs.joc.6b00925

upstream raw materials:

4-Fluorothiophenol

diethyl chlorophosphate

phosphonic acid diethyl ester

4-fluoro-2,4,6-trimethyldiphenyliodonium trifluoromethanesulfonate

Downstream raw materials:

4-fluorophenyltetrafluoro-λ⁶-sulfanyl chloride

4-Fluorothiophenol

diethyl methyl phosphate

Refernces

• 1、 Guo, Xiaqun,Li, Meichao,Liu, Xin,Shen, Zhenlu,Shi, Shuxian,Wu, Zengzhi,Zhao, Lingmin. "Electrochemically driven synthesis of phosphorothioates from trialkyl phosphites and aryl thiols". . . Retrieved 2021/06/25.
• 2、 -. "Synthetic method of thiophosphate compound". Paragraph 0055-0056. . Retrieved 2020/05/30.