Indolizine, 8-fluorooctahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Base Information

Chemical Name:Indolizine, 8-fluorooctahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-
CAS No.:156150-90-2
Molecular Formula:C₂₉H₃₂FNO₃
Molecular Weight:461.576
Hs Code.:
Mol file:156150-90-2.mol

Synonyms:Indolizine, 8-fluorooctahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Suppliers and Price of Indolizine, 8-fluorooctahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of Indolizine, 8-fluorooctahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Chemical Property:

PSA：30.93000
LogP:5.10650

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Indolizine, 8-fluorooctahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

There total 4 articles about Indolizine, 8-fluorooctahydro-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79831-76-8
(1S,6S,7R,8R,8aR)-2,6,7,8-tetrahydroxy-indolizidine

: 156150-90-2
1,6,7-tri-O-benzyl-8-deoxy-8-fluorocastanospermine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.)Bu₂SnO, 2.) Bu₄NBr, 3.) LiH, Pr-SH / 1.) MePh, reflux, 2 h, 2.) MePh, reflux, 3 days, 3.) DMSO, 3 h

2: DAST / CH₂Cl₂ / 48 h

With 1-thiopropane; tetrabutylammomium bromide; lithium hydride; di(n-butyl)tin oxide; 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane;
DOI:10.1016/0040-4020(95)00803-G

Reference yield:

: 156150-89-9
1,6,7-tri-O-benzylcastanospermine

: 156150-91-3
1,2,7-tri-O-benzyl-8-fluoro-1(R),2(S),7(S),8(R),8a(R)-trihydroxyoctahydroindolizidine

: 156150-90-2
1,6,7-tri-O-benzyl-8-deoxy-8-fluorocastanospermine

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(00)76852-3

Reference yield:

: 100-39-0
benzyl bromide

: 156150-90-2
1,6,7-tri-O-benzyl-8-deoxy-8-fluorocastanospermine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.)Bu₂SnO, 2.) Bu₄NBr, 3.) LiH, Pr-SH / 1.) MePh, reflux, 2 h, 2.) MePh, reflux, 3 days, 3.) DMSO, 3 h

2: DAST / CH₂Cl₂ / 48 h

With 1-thiopropane; tetrabutylammomium bromide; lithium hydride; di(n-butyl)tin oxide; 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane;
DOI:10.1016/0040-4020(95)00803-G