[1-(5-bromo-2-hydroxy-benzyl)-5-methyl-1H-pyrazol-4-yl]acetic acid ethyl ester

Base Information

• Chemical Name: [1-(5-bromo-2-hydroxy-benzyl)-5-methyl-1H-pyrazol-4-yl]acetic acid ethyl ester
• CAS No.: 1444367-98-9
• Molecular Formula: C₁₅H₁₇BrN₂O₃
• Molecular Weight: 353.216
• Mol file: 1444367-98-9.mol

Synonyms:[1-(5-bromo-2-hydroxy-benzyl)-5-methyl-1H-pyrazol-4-yl]acetic acid ethyl ester

Chemical Property of [1-(5-bromo-2-hydroxy-benzyl)-5-methyl-1H-pyrazol-4-yl]acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of [1-(5-bromo-2-hydroxy-benzyl)-5-methyl-1H-pyrazol-4-yl]acetic acid ethyl ester

There total 2 articles about [1-(5-bromo-2-hydroxy-benzyl)-5-methyl-1H-pyrazol-4-yl]acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N'-(5-bromo-2-hydroxy-benzyl)-hydrazinecarboxylic acid tert-butyl ester (851205-58-8) + 3-[1-dimethylamino-methylidene]-4-oxo-pentanoic acid ethyl ester (66549-73-3) → [1-(5-bromo-2-hydroxy-benzyl)-5-methyl-1H-pyrazol-4-yl]acetic acid ethyl ester (1444367-98-9)

Guidance literature:

N'-(5-bromo-2-hydroxy-benzyl)-hydrazinecarboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

3-[1-dimethylamino-methylidene]-4-oxo-pentanoic acid ethyl ester; In ethanol; at 20 ℃; for 19h; Reflux;

Reference yield:

5-bromosalicyclaldehyde (1761-61-1) → [1-(5-bromo-2-hydroxy-benzyl)-5-methyl-1H-pyrazol-4-yl]acetic acid ethyl ester (1444367-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 20 °C

1.3: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.2: 19 h / 20 °C / Reflux

With acetic acid; trifluoroacetic acid; In dichloromethane;

Reference yield: 45.0%

2-ethyl-1-butanol (97-95-0) + [1-(5-bromo-2-hydroxy-benzyl)-5-methyl-1H-pyrazol-4-yl]acetic acid ethyl ester (1444367-98-9) → {1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-4-yl}-acetic acid ethyl ester (1444368-02-8)

Guidance literature:

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; toluene; at 120 ℃; for 0.333333h; Microwave irradiation;

upstream raw materials:

5-bromosalicyclaldehyde

N'-(5-bromo-2-hydroxy-benzyl)-hydrazinecarboxylic acid tert-butyl ester

3-[1-dimethylamino-methylidene]-4-oxo-pentanoic acid ethyl ester

Downstream raw materials:

{1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-4-yl}-acetic acid

{1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-4-yl}-acetic acid ethyl ester