{1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-4-yl}-acetic acid

Base Information

Chemical Name:{1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-4-yl}-acetic acid
CAS No.:1444367-26-3
Molecular Formula:C₁₉H₂₅BrN₂O₃
Molecular Weight:409.323
Hs Code.:

Synonyms:{1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-4-yl}-acetic acid

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Chemical Property of {1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-4-yl}-acetic acid

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Technology Process of {1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-4-yl}-acetic acid

There total 4 articles about {1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-4-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1444368-02-8
{1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-4-yl}-acetic acid ethyl ester

: 1444367-26-3
{1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-4-yl}-acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 100 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 851205-58-8
N'-(5-bromo-2-hydroxy-benzyl)-hydrazinecarboxylic acid tert-butyl ester

: 1444367-26-3
{1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-4-yl}-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

1.2: 19 h / 20 °C / Reflux

2.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran; toluene / 0.33 h / 120 °C / Microwave irradiation

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.33 h / 100 °C / Microwave irradiation

With di-tert-butyl-diazodicarboxylate; water; triphenylphosphine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 1444367-98-9
[1-(5-bromo-2-hydroxy-benzyl)-5-methyl-1H-pyrazol-4-yl]acetic acid ethyl ester

: 1444367-26-3
{1-[5-bromo-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-4-yl}-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran; toluene / 0.33 h / 120 °C / Microwave irradiation

2: water; lithium hydroxide / tetrahydrofuran; methanol / 0.33 h / 100 °C / Microwave irradiation

With di-tert-butyl-diazodicarboxylate; water; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; toluene;