1,6-Dimethylindoline-2-thione

Base Information

Chemical Name:1,6-Dimethylindoline-2-thione
CAS No.:156136-67-3
Molecular Formula:C₁₀H₁₁NS
Molecular Weight:177.27
Hs Code.:
DSSTox Substance ID:DTXSID301262682
Mol file:156136-67-3.mol

Synonyms:156136-67-3;1,6-Dimethylindoline-2-thione;1,6-dimethyl-3H-indole-2-thione;2H-Indole-2-thione, 1,3-dihydro-1,6-dimethyl-;SCHEMBL8999088;DTXSID301262682;1,3-Dihydro-1,6-dimethyl-2H-indole-2-thione

Suppliers and Price of 1,6-Dimethylindoline-2-thione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1,6-Dimethylindoline-2-thione

Chemical Property:

Boiling Point:285.0±50.0 °C(Predicted)
PKA:-0.62±0.20(Predicted)
PSA：35.33000
Density:1.19±0.1 g/cm3(Predicted)
LogP:2.37970
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:177.06122053
Heavy Atom Count:12
Complexity:202

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(CC(=S)N2C)C=C1

Technology Process of 1,6-Dimethylindoline-2-thione

There total 5 articles about 1,6-Dimethylindoline-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 156136-66-2
1-methyl-6-methyl-1,3-dihydroindol-2-one

: 156136-67-3
1,3-dihydro-1,6-dimethyl-2H-indole-2-thione

Guidance literature:: With tetraphosphorus decasulfide; sodium carbonate; In tetrahydrofuran; for 18h; Ambient temperature;
DOI:10.1021/jm00039a016

Reference yield:

: 95-78-3
2,5-Dimethylaniline

: 156136-67-3
1,3-dihydro-1,6-dimethyl-2H-indole-2-thione

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / ethanol; H₂O / 0.5 h / 20 °C

2: 99 percent / NaBH₄ / dioxane / 5 h / Heating

3: 1.) n-butyllithium, 3.) n-butyllithium, 5.) 0.1 M HCl

4: 91 percent / Na₂CO₃, P₂S₅ / tetrahydrofuran / 18 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; tetraphosphorus decasulfide; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; water;
DOI:10.1021/jm00039a016

Reference yield:

: 21354-48-3
2,5-dimethyl-N-methylaniline

: 156136-67-3
1,3-dihydro-1,6-dimethyl-2H-indole-2-thione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-butyllithium, 3.) n-butyllithium, 5.) 0.1 M HCl

2: 91 percent / Na₂CO₃, P₂S₅ / tetrahydrofuran / 18 h / Ambient temperature

With hydrogenchloride; n-butyllithium; tetraphosphorus decasulfide; sodium carbonate; In tetrahydrofuran;
DOI:10.1021/jm00039a016