2-fluoro-N-(8-methyl-3-{[(2-methylpropyl)amino]methyl}quinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Base Information

Chemical Name:2-fluoro-N-(8-methyl-3-{[(2-methylpropyl)amino]methyl}quinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide
CAS No.:1236404-91-3
Molecular Formula:C₂₇H₃₂FN₃O₃
Molecular Weight:465.568
Hs Code.:

Synonyms:2-fluoro-N-(8-methyl-3-{[(2-methylpropyl)amino]methyl}quinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Chemical Property of 2-fluoro-N-(8-methyl-3-{[(2-methylpropyl)amino]methyl}quinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Technology Process of 2-fluoro-N-(8-methyl-3-{[(2-methylpropyl)amino]methyl}quinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

There total 11 articles about 2-fluoro-N-(8-methyl-3-{[(2-methylpropyl)amino]methyl}quinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1236405-11-0
2-fluoro-N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

: 78-81-9
isobutylamine

: 1236404-91-3
2-fluoro-N-(8-methyl-3-{[(2-methylpropyl)amino]methyl}quinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: 2-fluoro-N-(3-formyl-8-methylquinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide; isobutylamine; With acetic acid; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 3h;

With sodium tris(acetoxy)borohydride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 3h;

With sodium hydroxide; In 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 87392-07-2
(S)-tetrahydro-2-furoic acid

: 1236404-91-3
2-fluoro-N-(8-methyl-3-{[(2-methylpropyl)amino]methyl}quinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene; hexane; methanol / 0.5 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2 h / 0 - 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 60 °C

4.2: 0 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C

6.1: triethylamine / ISOPROPYLAMIDE / 24 h / 20 °C / Cooling with ice

7.1: hydrogen / palladium on activated charcoal / methanol / 4 h / 20 °C

8.1: morpholine / butan-1-ol / 14 h / 80 °C

8.2: 2 h / 20 °C

9.1: acetic acid / 1-methyl-pyrrolidin-2-one / 3 h / 20 °C

9.2: 3 h / 20 °C

With morpholine; lithium aluminium tetrahydride; oxalyl dichloride; water; hydrogen; acetic acid; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; palladium on activated charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; hexane; ISOPROPYLAMIDE; toluene; butan-1-ol;

Reference yield:

: 65145-13-3
2-fluoro-4-hydroxybenzoic acid

: 1236404-91-3
2-fluoro-N-(8-methyl-3-{[(2-methylpropyl)amino]methyl}quinolin-7-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / 16 h / 90 °C

2.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2 h / 0 - 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 60 °C

3.2: 0 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C

5.1: triethylamine / ISOPROPYLAMIDE / 24 h / 20 °C / Cooling with ice

6.1: hydrogen / palladium on activated charcoal / methanol / 4 h / 20 °C

7.1: morpholine / butan-1-ol / 14 h / 80 °C

7.2: 2 h / 20 °C

8.1: acetic acid / 1-methyl-pyrrolidin-2-one / 3 h / 20 °C

8.2: 3 h / 20 °C

With morpholine; oxalyl dichloride; sulfuric acid; water; hydrogen; acetic acid; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; palladium on activated charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ISOPROPYLAMIDE; toluene; butan-1-ol;