(S)-2-Amino-6-((S)-2-{(3S,4S)-5-cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-hexanoic acid

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Chemical Name:(S)-2-Amino-6-((S)-2-{(3S,4S)-5-cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-hexanoic acid
CAS No.:128972-44-1
Molecular Formula:C₄₆H₆₅N₉O₆
Molecular Weight:840.079
Hs Code.:

(S)-2-Amino-6-((S)-2-{(3S,4S)-5-cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-hexanoic acid

Synonyms:(S)-2-Amino-6-((S)-2-{(3S,4S)-5-cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-hexanoic acid

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Chemical Property of (S)-2-Amino-6-((S)-2-{(3S,4S)-5-cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-hexanoic acid

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Technology Process of (S)-2-Amino-6-((S)-2-{(3S,4S)-5-cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-hexanoic acid

There total 21 articles about (S)-2-Amino-6-((S)-2-{(3S,4S)-5-cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3099-31-8
nicotinyl chloride

: 128972-44-1
(S)-2-Amino-6-((S)-2-{(3S,4S)-5-cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 2.) 2 h

2: 2 M aq. NaOH / ethanol / 1 h

3: triethylamine, 1-hydroxybenzotriazole (HOBT), ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 18 h / 20 °C

4: H₂ / 10percent Pd/C / ethanol

With sodium hydroxide; hydrogen; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a005

Reference yield:

: (S)-2-Benzyloxycarbonylamino-6-((S)-2-{(3S,4S)-5-cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-hexanoic acid benzyl ester

: 128972-44-1
(S)-2-Amino-6-((S)-2-{(3S,4S)-5-cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-hexanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00171a005

Reference yield:

: 5591-94-6
N^(α)-benzyloxycarbonyl-L-lysine benzyl ester

: 128972-44-1
(S)-2-Amino-6-((S)-2-{(3S,4S)-5-cyclohexyl-3-hydroxy-4-[2-(8-isobutyl-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-pentanoylamino}-4-methyl-pentanoylamino)-hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1-hydroxybenzotriazole (HOBT), 1-ethyl-3-<3-dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / dimethylformamide / 18 h

2: 4 M HCl / dioxane

3: triethylamine, 1-hydroxybenzotriazole (HOBT), ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 18 h / 20 °C

4: H₂ / 10percent Pd/C / ethanol

With hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a005