tetraethyl (2-bromo-1,4-phenylene)bis(methylene)diphosphonate

Base Information

• Chemical Name: tetraethyl (2-bromo-1,4-phenylene)bis(methylene)diphosphonate
• CAS No.: 346691-69-8
• Molecular Formula: C₁₆H₂₇BrO₆P₂
• Molecular Weight: 457.238
• Mol file: 346691-69-8.mol

Synonyms:tetraethyl (2-bromo-1,4-phenylene)bis(methylene)diphosphonate

Chemical Property of tetraethyl (2-bromo-1,4-phenylene)bis(methylene)diphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of tetraethyl (2-bromo-1,4-phenylene)bis(methylene)diphosphonate

There total 2 articles about tetraethyl (2-bromo-1,4-phenylene)bis(methylene)diphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1,4-bisbromomethyl-2-bromobenzene (19900-52-8) + triethyl phosphite (122-52-1) → tetraethyl (2-bromo-1,4-phenylene)bis(methylene)diphosphonate (346691-69-8)

Guidance literature:

at 160 ℃; for 4h;

DOI:10.1021/jm010045q

Reference yield:

4-bromo-m-xylene (553-94-6) → tetraethyl (2-bromo-1,4-phenylene)bis(methylene)diphosphonate (346691-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; 2: |Arbuzov Reaction;

DOI:10.1016/j.bmcl.2014.09.075

Reference yield: 44.5%

methyl 5-formyl-2-methoxybenzoate (78515-16-9) + tetraethyl (2-bromo-1,4-phenylene)bis(methylene)diphosphonate (346691-69-8) → (E,E)-1-bromo-2,5-bis-(3-methoxycarbonyl-4-methoxy)styrylbenzene (346691-70-1)

Guidance literature:

With sodium methylate; In methanol; Heating;

DOI:10.1021/jm010045q

upstream raw materials:

1,4-bisbromomethyl-2-bromobenzene

triethyl phosphite

4-bromo-m-xylene

Downstream raw materials:

(E,E)-1-bromo-2,5-bis-(3-methoxycarbonyl-4-methoxy)styrylbenzene

(E,E)-2,5-bis(4’-hydroxy-3’-carboxystyryl)-1-bromobenzene

(E,E)-2,5-bis(4’-hydroxy-3’-carbomethoxystyryl)-1-iodobenzene

(E,E)-2,5-bis(4’-methoxy-3’-carbomethoxystyryl)-1-iodobenzene