78515-16-9

Basic information

• Product Name: Methyl 5-formyl-2-methoxybenzoate
• Synonyms: methyl5-formyl-2-methoxybenzoate;Benzoic acid, 5-formyl-2-methoxy-, methyl ester;5-formyl-2-methoxybenzamide;EOS-61914;Eluxadoline Intermediate 3
• CAS NO: 78515-16-9
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.18
• Product Categories: Acids and Derivatives;Carbonyl Compounds;API intermediates
• Mol File: 78515-16-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 86-87 °C
• Boiling Point: 332.268°C at 760 mmHg
• Flash Point: 148.155°C
• Appearance: /
• Density: 1.191g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Methyl 5-formyl-2-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-formyl-2-methoxybenzoate(78515-16-9)
• EPA Substance Registry System: Methyl 5-formyl-2-methoxybenzoate(78515-16-9)

Safety Data

• Hazardous Substances Data: 78515-16-9(Hazardous Substances Data)

Usage

Uses

Methyl 5-Formyl-2-methoxybenzoate is an intermediate used to synthesize peroxisome proliferator-activated receptor (PPAR) activators. It is also used to prepare 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene derivatives as PTP1B inhibitors.

InChI:InChI=1/C10H10O4/c1-13-9-4-3-7(6-11)5-8(9)10(12)14-2/h3-6H,1-2H3

Upstream product

• 616-76-2 2-hydroxy-5-formylbenzoic acid 
• 74-88-4 methyl iodide 
• 41489-76-3 methyl-5-formyl-2-hydroxybenzoate 
• 69-72-7 salicylic acid 
• 77-78-1 dimethyl sulfate 
• 75-75-2 methanesulfonic acid 
• 100-97-0 hexamethylenetetramine 
• 606-45-1 2-methoxybenzoic acid methyl ester 

Downstream Products

• 191605-12-6 methyl 5-((hydroxyimino)methyl)-2-methoxybenzoate 
• 185808-44-0 N-(3,5-bis-trifluoromethyl-benzyl)-5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-benzamide 
• 186312-77-6 5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-benzamide 
• 186312-78-7 5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-N-ethyl-2-methoxy-N-(4-trifluoromethyl-benzyl)-benzamide 
• 185808-47-3 5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-N-(4-trifluoromethoxy-benzyl)-benzamide 
• 185808-43-9 5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-N-(2-trifluoromethyl-benzyl)-benzamide 
• 185808-41-7 5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-N-(3-trifluoromethyl-benzyl)-benzamide 
• 185808-46-2 N-(4-tert-butyl-benzyl)-5-(2,4-dioxo-thiazolidin-5-ylidenemethyl)-2-methoxy-benzamide 

Relevant articles and documents

Electricity Driven 1,3-Oxohydroxylation of Donor-Acceptor Cyclopropanes: a Mild and Straightforward Access to β-Hydroxy Ketones

An unprecedented external oxidant-free electrochemical protocol for 1, 3-oxohydroxylation of donor-acceptor cyclopropane is disclosed. The strategy encompasses the activation of the labile π-electron cloud of the aryl ring to cleave the strained Csp3?Csp3 bond of cyclopropane to afford the β-hydroxy ketones via insertion of molecular oxygen. More significantly, based on the detailed mechanistic investigations and cyclic voltammetry experiments, a plausible mechanism is proposed.

Preparation method of methyl 5-formyl-2-methoxybenzoate

The invention discloses a preparation method of methyl 5-formyl-2-methoxybenzoate. The preparation method comprises following steps: (1), preparation of methyl-2-methoxybenzoate; (2), preparation of methyl 5-formyl-2-methoxybenzoate. With the adoption of the method for loading an aldehyde group by urotropine after ester formation, the total yield can be increased to about 90%, the utilization rateof the raw materials is greatly increased, the cost is low, the operation is simple and convenient, and industrialization is facilitated.

SPIRO-SUBSTITUTED OXINDOLE DERIVATIVES HAVING AMPK ACTIVITY

The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.