7,9-bis[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-8-azaspiro[4.5]deca-6,9-diene

Base Information

• Chemical Name: 7,9-bis[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-8-azaspiro[4.5]deca-6,9-diene
• CAS No.: 854280-08-3
• Molecular Formula: C₃₈H₃₉NO₁₀P₂
• Molecular Weight: 731.676
• Mol file: 854280-08-3.mol

Synonyms:7,9-bis[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-8-azaspiro[4.5]deca-6,9-diene

Chemical Property of 7,9-bis[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-8-azaspiro[4.5]deca-6,9-diene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7,9-bis[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-8-azaspiro[4.5]deca-6,9-diene

There total 3 articles about 7,9-bis[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-8-azaspiro[4.5]deca-6,9-diene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

8-(tert-butoxycarbonyl)-7,9-dioxo-8-azaspiro[4.5]decane (854280-06-1) + chlorophosphoric acid diphenyl ester (2524-64-3) → 7,9-bis[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-8-azaspiro[4.5]deca-6,9-diene (854280-08-3)

Guidance literature:

8-(tert-butoxycarbonyl)-7,9-dioxo-8-azaspiro[4.5]decane; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

chlorophosphoric acid diphenyl ester; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 15h;

DOI:10.1016/j.tetlet.2005.03.136

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 7,9-bis[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-8-azaspiro[4.5]deca-6,9-diene (854280-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 95 percent / DMAP / acetonitrile / 15 h / 20 °C

2.1: LDA / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 70 percent / tetrahydrofuran; hexane / 15 h / -78 - 20 °C

With dmap; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetonitrile;

DOI:10.1016/j.tetlet.2005.03.136

Reference yield:

tetramethylene glutarimide (1075-89-4) → 7,9-bis[di(phenyloxy)phosphoryloxy]-8-(tert-butoxycarbonyl)-8-azaspiro[4.5]deca-6,9-diene (854280-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 95 percent / DMAP / acetonitrile / 15 h / 20 °C

2.1: LDA / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 70 percent / tetrahydrofuran; hexane / 15 h / -78 - 20 °C

With dmap; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetonitrile;

DOI:10.1016/j.tetlet.2005.03.136

upstream raw materials:

8-(tert-butoxycarbonyl)-7,9-dioxo-8-azaspiro[4.5]decane

chlorophosphoric acid diphenyl ester

di-tert-butyl dicarbonate

tetramethylene glutarimide