3,3-diethyl-4-<<4-<(1,1-dimethylethoxy)carbonyl>phenyl>oxy>-1-<<<(4-carbamoylphenyl)methyl>amino>carbonyl>-2-azetidinone

Base Information

Chemical Name:3,3-diethyl-4-<<4-<(1,1-dimethylethoxy)carbonyl>phenyl>oxy>-1-<<<(4-carbamoylphenyl)methyl>amino>carbonyl>-2-azetidinone
CAS No.:143819-00-5
Molecular Formula:C₂₇H₃₃N₃O₆
Molecular Weight:495.576
Hs Code.:

Synonyms:3,3-diethyl-4-<<4-<(1,1-dimethylethoxy)carbonyl>phenyl>oxy>-1-<<<(4-carbamoylphenyl)methyl>amino>carbonyl>-2-azetidinone

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Chemical Property of 3,3-diethyl-4-<<4-<(1,1-dimethylethoxy)carbonyl>phenyl>oxy>-1-<<<(4-carbamoylphenyl)methyl>amino>carbonyl>-2-azetidinone

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Technology Process of 3,3-diethyl-4-<<4-<(1,1-dimethylethoxy)carbonyl>phenyl>oxy>-1-<<<(4-carbamoylphenyl)methyl>amino>carbonyl>-2-azetidinone

There total 10 articles about 3,3-diethyl-4-<<4-<(1,1-dimethylethoxy)carbonyl>phenyl>oxy>-1-<<<(4-carbamoylphenyl)methyl>amino>carbonyl>-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[1-(4-Chlorocarbonyl-benzylcarbamoyl)-3,3-diethyl-4-oxo-azetidin-2-yloxy]-benzoic acid tert-butyl ester

: 143819-00-5
3,3-diethyl-4-<<4-<(1,1-dimethylethoxy)carbonyl>phenyl>oxy>-1-<<<(4-carbamoylphenyl)methyl>amino>carbonyl>-2-azetidinone

Guidance literature:: With ammonium hydroxide; In dichloromethane; for 0.5h; Yield given;
DOI:10.1021/jm00099a003

Reference yield:

: 56-91-7
p-aminomethylbenzoic acid

: 143819-00-5
3,3-diethyl-4-<<4-<(1,1-dimethylethoxy)carbonyl>phenyl>oxy>-1-<<<(4-carbamoylphenyl)methyl>amino>carbonyl>-2-azetidinone

Guidance literature:: Multi-step reaction with 6 steps

1: Heating

2: 3.2 g / toluene / 2 h / Ambient temperature

3: triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / Heating

4: 1.2 N HCl

5: oxalyl chloride, dimethylformamide / CH₂Cl₂ / 0.5 h

6: NH₄OH / CH₂Cl₂ / 0.5 h

With hydrogenchloride; dmap; ammonium hydroxide; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1021/jm00099a003

Reference yield:

: 97-96-1
2-Ethylbutyraldehyde

: 143819-00-5
3,3-diethyl-4-<<4-<(1,1-dimethylethoxy)carbonyl>phenyl>oxy>-1-<<<(4-carbamoylphenyl)methyl>amino>carbonyl>-2-azetidinone

Guidance literature:: Multi-step reaction with 7 steps

1: 55 percent / sodium acetate / 48 h / Heating

2: 36 percent / CH₂Cl₂ / Ambient temperature

3: 85 percent / acetone / 0.5 h

4: triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / Heating

5: 1.2 N HCl

6: oxalyl chloride, dimethylformamide / CH₂Cl₂ / 0.5 h

7: NH₄OH / CH₂Cl₂ / 0.5 h

With hydrogenchloride; dmap; ammonium hydroxide; oxalyl dichloride; sodium acetate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; acetone;
DOI:10.1021/jm00099a003