(E)-N-(4-(3-(5-amino-1-methyl-1H-benzo[e]indol-3(2H)-yl)-3-oxoprop-1-enyl)benzyl)-N,N-dimethyl-1-(1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methanaminium bromide hydrobromide

Base Information

Chemical Name:(E)-N-(4-(3-(5-amino-1-methyl-1H-benzo[e]indol-3(2H)-yl)-3-oxoprop-1-enyl)benzyl)-N,N-dimethyl-1-(1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methanaminium bromide hydrobromide
CAS No.:1357580-62-1
Molecular Formula:BrH*Br*C₃₂H₃₇N₄O₃S
Molecular Weight:718.553
Hs Code.:

(E)-N-(4-(3-(5-amino-1-methyl-1H-benzo[e]indol-3(2H)-yl)-3-oxoprop-1-enyl)benzyl)-N,N-dimethyl-1-(1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methanaminium bromide hydrobromide

Synonyms:(E)-N-(4-(3-(5-amino-1-methyl-1H-benzo[e]indol-3(2H)-yl)-3-oxoprop-1-enyl)benzyl)-N,N-dimethyl-1-(1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methanaminium bromide hydrobromide

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Chemical Property of (E)-N-(4-(3-(5-amino-1-methyl-1H-benzo[e]indol-3(2H)-yl)-3-oxoprop-1-enyl)benzyl)-N,N-dimethyl-1-(1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methanaminium bromide hydrobromide

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Technology Process of (E)-N-(4-(3-(5-amino-1-methyl-1H-benzo[e]indol-3(2H)-yl)-3-oxoprop-1-enyl)benzyl)-N,N-dimethyl-1-(1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methanaminium bromide hydrobromide

There total 11 articles about (E)-N-(4-(3-(5-amino-1-methyl-1H-benzo[e]indol-3(2H)-yl)-3-oxoprop-1-enyl)benzyl)-N,N-dimethyl-1-(1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methanaminium bromide hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1017279-18-3
N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]-amino-1-methyl-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

: 1357580-62-1
(E)-N-(4-(3-(5-amino-1-methyl-1H-benzo[e]indol-3(2H)-yl)-3-oxoprop-1-enyl)benzyl)-N,N-dimethyl-1-(1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methanaminium bromide hydrobromide

Guidance literature:: N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]-amino-1-methyl-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 15h; Darkness;

In methanol;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: 1017279-12-7
5-allylamino-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1-methyl-1,2-dihydro-3H-benzo[e]indole

: 1357580-62-1
(E)-N-(4-(3-(5-amino-1-methyl-1H-benzo[e]indol-3(2H)-yl)-3-oxoprop-1-enyl)benzyl)-N,N-dimethyl-1-(1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methanaminium bromide hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: dmap / 1,4-dioxane / 48 h / Reflux

3.1: tetrahydrofuran / 85 h / 20 °C / Inert atmosphere; Darkness

4.1: hydrogenchloride / 1,4-dioxane / 15 h / 20 °C / Darkness

4.2: Biorad AG-1X₄ resin Cl^(1-)-form

With hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: 1017279-11-6
5-[allyl(tert-butoxycarbonyl)amino]-3-(tert-butoxycarbonyl)-1-methyl-1,2-dihydro-3H-benzo[e]indole

: 1357580-62-1
(E)-N-(4-(3-(5-amino-1-methyl-1H-benzo[e]indol-3(2H)-yl)-3-oxoprop-1-enyl)benzyl)-N,N-dimethyl-1-(1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl)methanaminium bromide hydrobromide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / 0 - 20 °C

2.1: tetrahydrofuran / 12 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: dmap / 1,4-dioxane / 48 h / Reflux

5.1: tetrahydrofuran / 85 h / 20 °C / Inert atmosphere; Darkness

6.1: hydrogenchloride / 1,4-dioxane / 15 h / 20 °C / Darkness

6.2: Biorad AG-1X₄ resin Cl^(1-)-form

With hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2011.12.007