N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]-amino-1-methyl-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

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Chemical Name:N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]-amino-1-methyl-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide
CAS No.:1017279-18-3
Molecular Formula:Br*C₄₂H₅₃N₄O₇S
Molecular Weight:837.875
Hs Code.:

N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]-amino-1-methyl-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

Synonyms:N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]-amino-1-methyl-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

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Chemical Property of N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]-amino-1-methyl-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

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Technology Process of N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]-amino-1-methyl-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

There total 10 articles about N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]-amino-1-methyl-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1017279-03-6
2-(bromomethyl)-1-methyl-5-(methylsulfonyl)pyrrole

: 1017279-15-0
5-[bis(tert-butoxycarbonyl)]amino-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1-methyl-1,2-dihydro-3H-benzo[e]indole

: 1017279-18-3
N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]-amino-1-methyl-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 85h; Inert atmosphere; Darkness;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: 1017279-12-7
5-allylamino-3-[(E)-4-(dimethylaminomethyl)cinnamoyl]-1-methyl-1,2-dihydro-3H-benzo[e]indole

: 1017279-18-3
N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]-amino-1-methyl-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: dmap / 1,4-dioxane / 48 h / Reflux

3.1: tetrahydrofuran / 85 h / 20 °C / Inert atmosphere; Darkness

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2011.12.007

Reference yield:

: 1017279-11-6
5-[allyl(tert-butoxycarbonyl)amino]-3-(tert-butoxycarbonyl)-1-methyl-1,2-dihydro-3H-benzo[e]indole

: 1017279-18-3
N-4-((E)-3-{5-[bis(tert-butoxycarbonyl)]-amino-1-methyl-1,2-dihydro-3H-benzo[e]indol-3-yl}-3-oxo-1-propenyl)benzyl-N,N-dimethyl-N-[(1-methyl-5-methylsulfonyl-2-pyrrolyl)methyl]ammonium bromide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / 0 - 20 °C

2.1: tetrahydrofuran / 12 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: dmap / 1,4-dioxane / 48 h / Reflux

5.1: tetrahydrofuran / 85 h / 20 °C / Inert atmosphere; Darkness

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; sodium benzenesulfonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmc.2011.12.007