{6-[(4-fluorophenyl)-carbonyl]-2,1,3-benzothiadiazol-5-yl}-methanesulfonic acid chloride

Base Information

Chemical Name:{6-[(4-fluorophenyl)-carbonyl]-2,1,3-benzothiadiazol-5-yl}-methanesulfonic acid chloride
CAS No.:1282510-38-6
Molecular Formula:C₁₄H₈ClFN₂O₃S₂
Molecular Weight:370.813
Hs Code.:

Synonyms:{6-[(4-fluorophenyl)-carbonyl]-2,1,3-benzothiadiazol-5-yl}-methanesulfonic acid chloride

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Chemical Property of {6-[(4-fluorophenyl)-carbonyl]-2,1,3-benzothiadiazol-5-yl}-methanesulfonic acid chloride

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Technology Process of {6-[(4-fluorophenyl)-carbonyl]-2,1,3-benzothiadiazol-5-yl}-methanesulfonic acid chloride

There total 4 articles about {6-[(4-fluorophenyl)-carbonyl]-2,1,3-benzothiadiazol-5-yl}-methanesulfonic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1282510-22-8
sodium [6-[(4-fluoro-phenyl)-carbonyl]-2,1,3-benzothiadiazole-5-yl]-methanesulfonate

: 1282510-38-6
{6-[(4-fluorophenyl)-carbonyl]-2,1,3-benzothiadiazol-5-yl}-methanesulfonic acid chloride

Guidance literature:: With thionyl chloride; for 2.5h; Reflux;

Reference yield:

: [6-(chloromethyl)-2,1,3-benzothiadiazol-5-yl](4-fluorophenyl)methanone

: 1282510-38-6
{6-[(4-fluorophenyl)-carbonyl]-2,1,3-benzothiadiazol-5-yl}-methanesulfonic acid chloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium sulfite / water; 1,4-dioxane / 2 h / Reflux

2: thionyl chloride / 3 h / Reflux

With thionyl chloride; sodium sulfite; In 1,4-dioxane; water;
DOI:10.1002/jhet.2141

Reference yield:

: 1376450-72-4
5H,7H-furo[3,4-f][2,1,3]benzothiadiazol-5-one

: 1282510-38-6
{6-[(4-fluorophenyl)-carbonyl]-2,1,3-benzothiadiazol-5-yl}-methanesulfonic acid chloride

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride; boron trifluoride diethyl etherate; N-benzyl-N,N,N-triethylammonium chloride / 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Reflux

2: aluminum (III) chloride / dichloromethane / 2 h / 0 - 20 °C

3: sodium sulfite / water; 1,4-dioxane / 2 h / Reflux

4: thionyl chloride / 3 h / Reflux

With aluminum (III) chloride; thionyl chloride; boron trifluoride diethyl etherate; N-benzyl-N,N,N-triethylammonium chloride; sodium sulfite; In 1,4-dioxane; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water;
DOI:10.1002/jhet.2141