1-[4-(pyridine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine

Base Information

Chemical Name:1-[4-(pyridine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine
CAS No.:1100768-08-8
Molecular Formula:C₁₄H₁₃F₃N₂O₂S
Molecular Weight:330.331
Hs Code.:

Synonyms:1-[4-(pyridine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine

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Chemical Property of 1-[4-(pyridine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine

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Technology Process of 1-[4-(pyridine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine

There total 5 articles about 1-[4-(pyridine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1100768-07-7
1-[4-(pyridine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethanone

: 1100768-08-8
1-[4-(pyridine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine

Guidance literature:: With ammonium acetate; sodium cyanoborohydride; In methanol; at 20 ℃; for 16h;

Reference yield:

: 129825-11-2
1-(4-chloro-3-(trifluoromethyl)phenyl)ethanone

: 1100768-08-8
1-[4-(pyridine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogensulfide / 1-methyl-pyrrolidin-2-one / 3 h / 140 - 160 °C

2: N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 150 °C / microwave

3: Oxone / tetrahydrofuran; methanol; water / 96 h / 0 - 20 °C

4: ammonium acetate; sodium cyanoborohydride / methanol / 16 h / 20 °C

With Oxone; sodium hydrogensulfide; ammonium acetate; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; water;

Reference yield:

: 1120-87-2
4-bromopyridin

: 1100768-08-8
1-[4-(pyridine-4-sulfonyl)-3-trifluoromethyl-phenyl]-ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 150 °C / microwave

2: Oxone / tetrahydrofuran; methanol; water / 96 h / 0 - 20 °C

3: ammonium acetate; sodium cyanoborohydride / methanol / 16 h / 20 °C

With Oxone; ammonium acetate; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water;