3'-(4-Fluorophenyl)spiro[cyclopentane-1,1'-[1H]indene]-2'-carboxaldehyde

Base Information

Chemical Name:3'-(4-Fluorophenyl)spiro[cyclopentane-1,1'-[1H]indene]-2'-carboxaldehyde
CAS No.:119899-77-3
Molecular Formula:C₂₀H₁₇FO
Molecular Weight:292.353
Hs Code.:

Synonyms:3'-(4-Fluorophenyl)spiro[cyclopentane-1,1'-[1H]indene]-2'-carboxaldehyde

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Chemical Property of 3'-(4-Fluorophenyl)spiro[cyclopentane-1,1'-[1H]indene]-2'-carboxaldehyde

Chemical Property:

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Technology Process of 3'-(4-Fluorophenyl)spiro[cyclopentane-1,1'-[1H]indene]-2'-carboxaldehyde

There total 1 articles about 3'-(4-Fluorophenyl)spiro[cyclopentane-1,1'-[1H]indene]-2'-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4885-02-3
Dichloromethyl methyl ether

: 119899-76-2
3'-(4-Fluorophenyl)spiro[cyclopentane-1,1'-1H]indene

: 119899-77-3
3'-(4-Fluorophenyl)spiro[cyclopentane-1,1'-[1H]indene]-2'-carboxaldehyde

Guidance literature:: TiCl₄; In hexane; dichloromethane;

Reference yield:

: 119899-77-3
3'-(4-Fluorophenyl)spiro[cyclopentane-1,1'-[1H]indene]-2'-carboxaldehyde

: C₂₃H₂₄FO₃P

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / -78 °C

2: p-toluenesulfonic acid / benzene / Heating

With toluene-4-sulfonic acid; In tetrahydrofuran; benzene;
DOI:10.1021/jm00173a007

Reference yield:

: 119899-77-3
3'-(4-Fluorophenyl)spiro[cyclopentane-1,1'-[1H]indene]-2'-carboxaldehyde

: C₂₂H₂₁ClFO₂P

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / -78 °C

2: p-toluenesulfonic acid / benzene / Heating

3: 1 N LiOH / dioxane

4: CH₂Cl₂

5: oxalyl chloride, DMF / CH₂Cl₂

With lithium hydroxide; oxalyl dichloride; toluene-4-sulfonic acid; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; benzene;
DOI:10.1021/jm00173a007