3-(2-(5-cyclohexyl-1-(2-oxo-propyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-benzoic acid

Base Information

Chemical Name:3-(2-(5-cyclohexyl-1-(2-oxo-propyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-benzoic acid
CAS No.:528882-53-3
Molecular Formula:C₂₆H₂₈N₄O₅
Molecular Weight:476.532
Hs Code.:

Synonyms:3-(2-(5-cyclohexyl-1-(2-oxo-propyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-benzoic acid

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Chemical Property of 3-(2-(5-cyclohexyl-1-(2-oxo-propyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-benzoic acid

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Technology Process of 3-(2-(5-cyclohexyl-1-(2-oxo-propyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-benzoic acid

There total 7 articles about 3-(2-(5-cyclohexyl-1-(2-oxo-propyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 942231-97-2
C₂₇H₃₀N₄O₅

: 528882-53-3
3-(2-(5-cyclohexyl-1-(2-oxo-propyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-benzoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1021/jm070139l

Reference yield:

: 528882-09-9
(5-cyclohexyl-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid ethyl ester

: 528882-53-3
3-(2-(5-cyclohexyl-1-(2-oxo-propyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / K₂CO₃; KI / acetonitrile / 64 h / Heating

2: 90 percent / aq. NaOH / ethanol / 16 h / 20 °C

3: 31 percent / HOBt; DMAP; EDCI / dimethylformamide / 16 h / 20 °C

4: 94 percent / aq. LiOH / tetrahydrofuran / 16 h / 20 °C

With dmap; lithium hydroxide; sodium hydroxide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm070139l

Reference yield:

: 528882-54-4
(5-cyclohexyl-1-(2-oxo-propyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid ethyl ester

: 528882-53-3
3-(2-(5-cyclohexyl-1-(2-oxo-propyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetylamino)-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / aq. NaOH / ethanol / 16 h / 20 °C

2: 31 percent / HOBt; DMAP; EDCI / dimethylformamide / 16 h / 20 °C

3: 94 percent / aq. LiOH / tetrahydrofuran / 16 h / 20 °C

With dmap; lithium hydroxide; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm070139l