1',1'-bis(t-butyldimethylsilyloxymethyl)-1-(4,4'-dimethoxytrityloxy)acetone

Base Information

Chemical Name:1',1'-bis(t-butyldimethylsilyloxymethyl)-1-(4,4'-dimethoxytrityloxy)acetone
CAS No.:289486-07-3
Molecular Formula:C₃₈H₅₆O₆Si₂
Molecular Weight:665.03
Hs Code.:

Synonyms:1',1'-bis(t-butyldimethylsilyloxymethyl)-1-(4,4'-dimethoxytrityloxy)acetone

Suppliers and Price of 1',1'-bis(t-butyldimethylsilyloxymethyl)-1-(4,4'-dimethoxytrityloxy)acetone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1',1'-bis(t-butyldimethylsilyloxymethyl)-1-(4,4'-dimethoxytrityloxy)acetone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1',1'-bis(t-butyldimethylsilyloxymethyl)-1-(4,4'-dimethoxytrityloxy)acetone

There total 7 articles about 1',1'-bis(t-butyldimethylsilyloxymethyl)-1-(4,4'-dimethoxytrityloxy)acetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 289486-26-6
1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-dimethyl-silanyloxymethyl)-butan-2-ol

: 289486-07-3
1',1'-bis(t-butyldimethylsilyloxymethyl)-1-(4,4'-dimethoxytrityloxy)acetone

Guidance literature:: With pyridine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dimethyl sulfoxide; at 20 ℃; for 5h;
DOI:10.1080/15257770008033028

Reference yield:

: 127382-65-4
1,3-bis-O-(tert-butyldimethylsilyl)-1,3-dihydroxy-2-propanone

: 289486-07-3
1',1'-bis(t-butyldimethylsilyloxymethyl)-1-(4,4'-dimethoxytrityloxy)acetone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 34.1 g / methanol / 30 h / 20 °C

2.1: 98 percent / DIBAL-H / diethyl ether / 2 h / -78 °C

3.1: 81 percent / Py / CH₂Cl₂ / 3 h / 20 °C

4.1: BH₃-SMe₂ / tetrahydrofuran / 2 h / 20 °C

4.2: 45 percent / NaBO₃; H₂O₂ / ethanol; H₂O / 0.33 h / 50 °C

5.1: 90 percent / DCC; Py; TFA / dimethylsulfoxide / 5 h / 20 °C

With pyridine; dimethylsulfide borane complex; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; 1.1: Wittig reaction / 2.1: Reduction / 3.1: Substitution / 4.1: Addition / 4.2: Oxidation / 5.1: Oxidation;
DOI:10.1080/15257770008033028

Reference yield:

: 85951-09-3
2,2,3,3,9,9,10,10-octamethyl-4,8-dioxa-3,9-disilaundecan-6-ol

: 289486-07-3
1',1'-bis(t-butyldimethylsilyloxymethyl)-1-(4,4'-dimethoxytrityloxy)acetone

Guidance literature:: Multi-step reaction with 6 steps

1.1: DCC; Py; TFA / dimethylsulfoxide / 24 h / 20 °C

2.1: 34.1 g / methanol / 30 h / 20 °C

3.1: 98 percent / DIBAL-H / diethyl ether / 2 h / -78 °C

4.1: 81 percent / Py / CH₂Cl₂ / 3 h / 20 °C

5.1: BH₃-SMe₂ / tetrahydrofuran / 2 h / 20 °C

5.2: 45 percent / NaBO₃; H₂O₂ / ethanol; H₂O / 0.33 h / 50 °C

6.1: 90 percent / DCC; Py; TFA / dimethylsulfoxide / 5 h / 20 °C

With pyridine; dimethylsulfide borane complex; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; 1.1: Oxidation / 2.1: Wittig reaction / 3.1: Reduction / 4.1: Substitution / 5.1: Addition / 5.2: Oxidation / 6.1: Oxidation;
DOI:10.1080/15257770008033028