(1R,2R,3S,4S,6R)-4-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-trioI

Base Information

Chemical Name:(1R,2R,3S,4S,6R)-4-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-trioI
CAS No.:1204221-10-2
Molecular Formula:C₂₁H₂₅ClO₅
Molecular Weight:397.84
Hs Code.:

Synonyms:(1R,2R,3S,4S,6R)-4-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-trioI

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Chemical Property of (1R,2R,3S,4S,6R)-4-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-trioI

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Technology Process of (1R,2R,3S,4S,6R)-4-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-trioI

There total 12 articles about (1R,2R,3S,4S,6R)-4-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-trioI which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: ((1R,2S,3S,6R)-6-(benzyloxymethyI)-4-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)cyclohex-4-ene-1,2,3-triyl)tris(oxy)tris(methylene)tribenzene

: 1204221-10-2
(1R,2R,3S,4S,6R)-4-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-trioI

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; for 1.5h;

Reference yield:

: 461432-22-4
(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone

: 1204221-10-2
(1R,2R,3S,4S,6R)-4-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-trioI

Guidance literature:: Multi-step reaction with 6 steps

1.1: aluminum (III) chloride; sodium borodeuteride / tetrahydrofuran / 5 - 70 °C

2.1: boron tribromide / dichloromethane / -60 - 25 °C

2.2: Cooling with ice

3.1: potassium carbonate / acetone / 20 - 75 °C

4.1: magnesium; ethylene dibromide / tetrahydrofuran / Reflux; Inert atmosphere

4.2: 3 h / 25 °C / Inert atmosphere

5.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / -25 °C

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1.5 h

With triethylsilane; aluminum (III) chloride; sodium borodeuteride; boron trifluoride diethyl etherate; hydrogen; boron tribromide; potassium carbonate; magnesium; ethylene dibromide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; acetone;

Reference yield:

: 21900-52-7
5-bromo-2-chloro-benzoyl chloride

: 1204221-10-2
(1R,2R,3S,4S,6R)-4-(4-chloro-3-((4-(methoxy-d3)phenyl)methyl-d2)phenyl)-6-(hydroxymethyl)cyclohexane-1,2,3-trioI

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride / dichloromethane / -3 - 4 °C / Industry scale

2.1: aluminum (III) chloride; sodium borodeuteride / tetrahydrofuran / 5 - 70 °C

3.1: boron tribromide / dichloromethane / -60 - 25 °C

3.2: Cooling with ice

4.1: potassium carbonate / acetone / 20 - 75 °C

5.1: magnesium; ethylene dibromide / tetrahydrofuran / Reflux; Inert atmosphere

5.2: 3 h / 25 °C / Inert atmosphere

6.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / -25 °C

7.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1.5 h

With triethylsilane; aluminum (III) chloride; sodium borodeuteride; boron trifluoride diethyl etherate; hydrogen; boron tribromide; potassium carbonate; magnesium; ethylene dibromide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; acetone;